Deep Brain Stimulation for Parkinson's Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how deep brain stimulation (DBS), a surgery that helps control Parkinson's disease symptoms, affects voice, swallowing, and coughing. It compares two brain targets for DBS: the subthalamic nucleus (STN) and the globus pallidus internal segment (GPi), to determine which is better for these functions. Suitable participants have Parkinson's disease, mild or moderate issues with voice or swallowing, and have been approved for DBS surgery. This research could guide doctors in selecting the best DBS target to improve patients' quality of life. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research that could enhance treatment options for future patients.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that deep brain stimulation is safe for people with Parkinson's disease?
Research shows that deep brain stimulation (DBS) surgery is generally safe for treating Parkinson's disease. When DBS targets the subthalamic nucleus (STN), studies have found it can greatly improve movement, with long-lasting benefits. Over five years, patients experienced improvements in daily activities without major safety issues.
Similarly, DBS targeting the globus pallidus internal segment (GPi) is also safe and effective for managing movement problems in advanced Parkinson's disease. The safety of both STN and GPi DBS is similar, with consistent results over time. While all surgeries carry risks, DBS remains a well-established method for helping people with Parkinson's disease.12345Why are researchers excited about this trial?
Researchers are excited about deep brain stimulation (DBS) for Parkinson's disease because it offers a more targeted approach compared to standard treatments like medication therapy with Levodopa or other dopamine agonists. Unlike these medications, which can have widespread effects throughout the body, DBS specifically targets areas in the brain responsible for motor control. The two DBS methods being explored—subthalamic nucleus (STN) and globus pallidus internus (GPi) stimulation—allow for precision in reducing symptoms like tremors and stiffness. This precision can lead to more significant improvements in quality of life and fewer side effects, making it a promising option for those with Parkinson's.
What evidence suggests that this trial's treatments could be effective for Parkinson's disease?
Research has shown that deep brain stimulation (DBS) effectively addresses movement problems in people with Parkinson's disease. In this trial, participants will receive DBS targeting either the subthalamic nucleus (STN) or the globus pallidus internal segment (GPi). Studies have found that DBS targeting the STN significantly improves movement and daily activities, with benefits lasting five years or more. Similarly, DBS aimed at the GPi reduces movement issues and medication-related problems. Both STN and GPi targets are safe and effective for controlling symptoms like tremors and involuntary movements. Overall, evidence supports that DBS at either target improves the quality of life for people with Parkinson's disease.14678
Who Is on the Research Team?
Karen Hegland, Ph.D.
Principal Investigator
University of Florida
Are You a Good Fit for This Trial?
This trial is for individuals with Parkinson's Disease considering Deep Brain Stimulation (DBS) surgery. It aims to understand how different DBS targets affect speech and swallowing functions. Participants should be eligible for the surgery but have not yet undergone it.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Pre-Surgery Evaluation
Participants undergo baseline assessments including laryngeal function, voice, cough, and swallowing evaluations prior to DBS surgery
Post-Surgery Follow-up
Participants are assessed for changes in laryngeal function, voice, cough, and swallowing after DBS surgery with stimulators on and off
Long-term Follow-up
Participants are monitored for any long-term changes in motor and non-motor symptoms related to DBS
What Are the Treatments Tested in This Trial?
Interventions
- Deep brain stimulation surgery - GPi
- Deep Brain Stimulation Surgery - STN
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Florida
Lead Sponsor
National Institute on Deafness and Other Communication Disorders (NIDCD)
Collaborator