High Resolution Gastric Mapping and Gastroduodenal Manometry for Indigestion

This trial aims to better understand and treat functional dyspepsia, a condition causing persistent stomach discomfort and indigestion. Researchers will study stomach movement and sensation, using advanced tools to track gastric activity and pressure. Participants will receive a treatment called tVNS (transcutaneous vagus nerve stimulation), a non-invasive method believed to help with these symptoms. This trial may suit those who have experienced symptoms of functional dyspepsia for at least six months. As an unphased trial, this study offers a unique opportunity to contribute to scientific understanding and potentially benefit from innovative treatment.

The trial information does not specify if you need to stop taking your current medications, but it does exclude those using opioids. It's best to discuss your specific medications with the trial coordinators.

Research has shown that transcutaneous auricular vagus nerve stimulation (tVNS) is safe for treating functional dyspepsia. One study reported no serious side effects with tVNS treatment. It improved symptoms without causing major problems, indicating that tVNS is generally well-tolerated.

For gastroduodenal manometry, studies primarily focus on its role in diagnosing dyspepsia rather than its safety as a treatment. This procedure helps understand stomach and intestinal function and is generally considered safe when performed by experienced healthcare providers.

Researchers are excited about this trial because it explores high-resolution gastric mapping and gastroduodenal manometry, combined with transcutaneous vagus nerve stimulation (tVNS), to better understand indigestion. Unlike traditional treatments, which often focus on medications like proton pump inhibitors or dietary changes, this trial investigates the body's gastric and nerve activity with innovative mapping techniques. tVNS is particularly intriguing because it non-invasively stimulates the vagus nerve, potentially offering a novel approach to managing symptoms by directly targeting nerve pathways involved in digestion. By mapping gastric activity in high resolution, researchers hope to uncover precise insights into the causes of indigestion and improve treatment strategies.

Research has shown that transcutaneous auricular vagal nerve stimulation (tVNS) might help with functional dyspepsia, a type of indigestion. In this trial, some participants will undergo gastroduodenal manometry with concurrent body surface gastric mapping while receiving tVNS. Studies found that using tVNS for four weeks greatly improved symptoms in adults with this condition and helped the stomach adjust better when eating. No serious side effects were reported, indicating it is a safe option. These findings suggest tVNS could effectively manage dyspepsia symptoms.⁶⁷⁸⁹¹⁰