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Bask GillCEO at Power
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      Why We Started Power

      We started Power when my dad was diagnosed with multiple myeloma, and I struggled to help him access the latest immunotherapy. Hopefully Power makes it simpler for you to explore promising new treatments, during what is probably a difficult time.

      Bask
      Bask GillCEO at Power
      Learn More About Trials
      How Do Clinical Trials Work?Are Clinical Trials Safe?What Can I Expect During a Clinical Trial?

      48 Migraine Trials Near You

      Power is an online platform that helps thousands of Migraine patients discover FDA-reviewed trials every day. Every trial we feature meets safety and ethical standards, giving patients an easy way to discover promising new treatments in the research stage.

      Learn More About Power
      No Placebo
      Highly Paid
      Stay on Current Meds
      Pivotal Trials (Near Approval)
      Breakthrough Medication

      Elismetrep for Migraine

      Cincinnati, Ohio
      This is a double-blind, randomized, multicenter, outpatient evaluation of the safety and efficacy of elismetrep as compared to placebo in the treatment of moderate or severe migraine.

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Phase 2

      Key Eligibility Criteria

      Disqualifiers:Uncontrolled Depression, Cardiovascular Disease, Others
      Must Not Be Taking:Opiates, Ergotamine, Others

      400 Participants Needed

      Brain Education and Wellness Program for Migraine

      Cincinnati, Ohio
      The goal of this randomized clinical trial is to evaluate two different non-drug, virtual treatment options designed to improve the lives of patients with migraine. Both interventions involve 8 weekly sessions and an online platform with additional content and learning. Participants can stay on all their medications during this study. Information from this study may help determine how to better treat migraine.
      No Placebo Group

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Unphased

      Key Eligibility Criteria

      Disqualifiers:Unstable Medical Condition, Medication Overuse, Heavy Alcohol, Others

      286 Participants Needed

      Atogepant + Botox for Chronic Migraine

      Cincinnati, Ohio
      This trial is testing a new daily pill called atogepant, used along with regular BOTOX treatments, to help prevent migraines. It targets adults who suffer from frequent and severe headaches. The pill works by blocking certain brain signals that trigger migraines. The study will monitor safety, side effects, and effectiveness over several months. Atogepant is a newly approved medication for the prevention of migraine.
      No Placebo Group
      Pivotal Trial (Near Approval)

      Trial Details

      Trial Status:Active Not Recruiting

      Key Eligibility Criteria

      Disqualifiers:Not Listed

      75 Participants Needed

      Fremanezumab for Preventing Chronic Migraine

      Cincinnati, Ohio
      The primary objective of the study is to evaluate the effectiveness of fremanezumab as compared to placebo for the preventive treatment of chronic migraine (CM). Secondary objectives are to further demonstrate the efficacy of Fremanezumab as compared to placebo for the preventive treatment of CM, to evaluate the safety and tolerability of Fremanezumab in the preventive treatment of CM and to evaluate the immunogenicity of Fremanezumab and the impact of antidrug antibodies (ADAs) on clinical outcomes in participants exposed to Fremanezumab The total duration of the study is planned to be 75 months.
      Pivotal Trial (Near Approval)

      Trial Details

      Trial Status:Active Not Recruiting
      Age:6 - 17

      Key Eligibility Criteria

      Disqualifiers:Not Listed

      278 Participants Needed

      Qudexy XR for Pediatric Migraine Prevention

      Cincinnati, Ohio
      A Phase 4 study to evaluate Qudexy XR for the prevention of migraine in children 6 to 11 years of age.

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Phase 4
      Age:6 - 11

      Key Eligibility Criteria

      Disqualifiers:Continuous Migraines, Allergic To Topiramate, Others
      Must Not Be Taking:Botox, Migraine Preventatives, Investigational Drugs

      132 Participants Needed

      Mind-Body Balance for Pediatric Migraine

      Cincinnati, Ohio
      This study uses a factorial research design to evaluate a nurse delivered mind body intervention using different doses of 3 treatment components to determine the optimized treatment for headache day reduction.
      No Placebo Group

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Unphased
      Age:10 - 17

      Key Eligibility Criteria

      Disqualifiers:Continuous Migraine, Severe Psychiatric Disease, Others
      Must Be Taking:Nutraceuticals, Anti-migraine

      260 Participants Needed

      Eptinezumab for Migraine

      Canton, Ohio
      The main goal of this trial is to learn whether eptinezumab improves migraine symptoms and quality of life of participants with migraine who did not perceive a sufficient improvement during previous treatment with therapies targeting calcitonin gene-related peptide (CGRP).
      No Placebo Group

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Phase 4

      Key Eligibility Criteria

      Disqualifiers:Cancer, Prostate Issues, Others
      Must Be Taking:Anti-CGRP MAb, Gepants

      150 Participants Needed

      Erenumab for Pediatric Migraine

      Cleveland, Ohio
      This study will evaluate the efficacy and safety of erenumab in migraine prevention in children (6 to \<12 years) and adolescents (12 to \<18 years) with episodic migraine. The study hypothesis is that in pediatric participants with episodic migraine, the combined erenumab dose group has a greater reduction from baseline to week 9 through week 12 (month 3) in monthly migraine days (MMDs) when compared with placebo in the double-blind treatment phase (DBTP).
      Pivotal Trial (Near Approval)

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Phase 3
      Age:6 - 17

      Key Eligibility Criteria

      Disqualifiers:Cluster Headache, Hemiplegic Migraine, Others
      Must Not Be Taking:Ergotamines, Triptans, Opioids, Others

      457 Participants Needed

      Erenumab for Migraine

      Cleveland, Ohio
      This trial tests if erenumab, an injection given regularly, can reduce migraine days in children and adolescents with chronic migraines by blocking a protein that triggers these headaches. Erenumab has been shown to reduce migraine days and improve quality of life in adults with chronic and episodic migraines.
      Pivotal Trial (Near Approval)

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Phase 3
      Age:6 - 17

      Key Eligibility Criteria

      Disqualifiers:Cluster Headache, Hemiplegic Migraine, No Response To 3+ Treatments, Suicidal Behavior, Major Psychiatric Disorder, Others

      284 Participants Needed

      Mindfulness Therapy for Migraines

      Cleveland, Ohio
      This trial is testing a type of therapy called Mindfulness-Based Cognitive Therapy, provided over the phone, through video calls, or as part of regular care with added support. It aims to help people with migraines and depressive symptoms by teaching them to focus on the present moment and understand their thought patterns better. Mindfulness-Based Cognitive Therapy (MBCT) was developed to prevent relapse in recurrent depression by combining cognitive behavioral therapy and meditative techniques.
      No Placebo Group

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Unphased

      Key Eligibility Criteria

      Disqualifiers:Psychiatric Illness, Cognitive Impairment, Others
      Must Not Be Taking:Antidepressants

      144 Participants Needed

      Atogepant for Migraine

      Ann Arbor, Michigan
      Migraine is a disease that most often causes moderate to severe headache on one side of the head. A migraine attack is a headache that may be accompanied by throbbing, nausea, vomiting, sensitivity to light and sound, or other symptoms. The goals of the study are to evaluate adverse events and how well treatment of atogepant works compared to placebo (looks like the study treatment but contains no medicine) in preventing chronic migraine in participants between 12 and 17 years of age. Atogepant is a medicine currently approved in the United States and Europe for the preventive treatment of migraine in adult patients with migraine and is being studied for the preventative treatment of chronic migraine in participants between the ages of 12 and 17 years. Participants will be randomly assigned to one of the 2 groups to be treated with either atogepant or placebo. This study is double-blinded, which means that neither the patients nor the study doctors know who is given which study treatment. Approximately 420 participants 12 to 17 years of age with chronic migraine will be enrolled at approximately 70 sites across the world. Participants will receive oral tablets of atogepant or placebo once daily for 12 weeks and will be followed for 4 weeks. Participants will attend regular visits during the study at a hospital or clinic and the effects of treatment will be checked by completion of a daily diary, medical assessments, blood tests, checking for side effects, and completing questionnaires.
      Pivotal Trial (Near Approval)

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Phase 3
      Age:12 - 17

      Key Eligibility Criteria

      Disqualifiers:Hypertension, Cardiovascular, Neurologic, Others

      420 Participants Needed

      Migraine Preventive Medications for Migraine

      Morgantown, West Virginia
      This goal of this study is to compare three medications used for migraine preventive treatment. This study will compare atogepant, a newer migraine preventive medication, with two older preventive medications, topiramate and propranolol. It will be determined if one works better and is more tolerable than the others. Research participants will: * Be randomly assigned to one of the three medications. * Provide information about their migraine pattern using a daily headache diary and during research visits.
      No Placebo Group

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Phase 4

      Key Eligibility Criteria

      Disqualifiers:Epilepsy, Severe Hepatic Impairment, Others
      Must Not Be Taking:CGRP-targeting, Beta-blockers, Opioids, Butalbital

      1335 Participants Needed

      Rimegepant for Migraine Prevention

      Ann Arbor, Michigan
      This study is being conducted to evaluate the efficacy and tolerability of rimegepant for migraine prophylaxis in adults with a history of inadequate response to oral preventive medications

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Phase 4
      Age:18 - 65

      Key Eligibility Criteria

      Disqualifiers:Cluster Headaches, Basilar Migraine, Chronic Pain, Others

      658 Participants Needed

      Rimegepant for Migraine

      Ann Arbor, Michigan
      This study is being conducted to evaluate the efficacy and tolerability of rimegepant in a population of adults that are unsuitable for triptan medications due to a previous intolerance, lack of efficacy, or contraindication (including a history of clinically-relevant cardiovascular disease).

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Phase 4
      Age:18 - 65

      Key Eligibility Criteria

      Disqualifiers:Cluster Headache, Chronic Pain, Others
      Must Not Be Taking:Triptans, CGRP Antagonists

      633 Participants Needed

      Behavioral Interventions for Chronic Migraine

      Ann Arbor, Michigan
      People with chronic migraine headaches face many challenges, including high levels of daily pain, disturbances to everyday activities and sleep, and problems with mood such as depression or anxiety. This trial is being completed to study whether changing an individual's behaviors may have an impact as a treatment for migraine headaches. Eligible participants will be randomized to one of the four arms. This study will be conducted remotely without in-person contact. Study Hypothesis: * There is a main effect of attending either the Empowered Relief and Health Education intervention on reductions in migraine-related disability 1 month after completing either intervention * There is a main effect of Empowered Relief and Health Education interventions on reducing pain-related catastrophizing and migraine symptom severity 1 month after completing either intervention (secondary hypothesis) * The expected reductions in migraine-related disability, pain catastrophizing, and migraine symptom severity will be maintained at secondary time points (2 months, 3 months, and 6 months after completing either intervention) (secondary hypothesis)
      No Placebo Group

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Unphased

      Key Eligibility Criteria

      Disqualifiers:Cognitive Impairment, Litigation, Others

      300 Participants Needed

      Brain Stimulation for Migraine

      Ann Arbor, Michigan
      This study investigates whether unilateral and bilateral non-invasive brain stimulation, given for 20 minutes/once per day for twenty days (M-F) can reduce migraine pain. Fourty patients will receive treatment (20 unilateral treatment, and 20 bilateral treatment), while twenty will receive a "sham" procedure. Another 20 Episodic Migraine patients will be recruited for the observational aim of the study which does not include brain stimulation.

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Unphased
      Age:18 - 65

      Key Eligibility Criteria

      Disqualifiers:Psychotic Disorders, Neurological Disorders, Others
      Must Not Be Taking:Opioids, Dopaminergics, Ergotamines, Others

      80 Participants Needed

      MMA Embolization for Migraine

      Morgantown, West Virginia
      This is a prospective, multi-center, feasibility study to investigate safety and effectiveness of TRUFILL n-BCA liquid embolic system in bilateral middle meningeal artery (MMA) embolization for the treatment of refractory chronic migraine.
      No Placebo Group

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Unphased
      Age:18 - 65

      Key Eligibility Criteria

      Disqualifiers:Other Headaches, Hemiplegic Migraine, Pregnant, Others
      Must Not Be Taking:Opioids, Cannabis

      50 Participants Needed

      MTX101 for Migraine

      Farmington Hills, Michigan
      The goal of this clinical trial is to learn if drug MTX101 works to treat acute migraine attacks in adults. It will also learn about the safety of the drug MTX101. The main questions it aims to answer are: Does the drug MTX101 lower headache pain for participants and the need to use a rescue medication? What side effects, if any, do participants have when taking the drug MTX101? Researchers will compare the drug MTX101 to a placebo (a look-alike substance that contains no drug) to see if the drug MTX101 works to treat acute migraine attacks. Participants will: Take the drug MTX101 or a placebo to treat 1 migraine attack with each treatment. Visit the clinic twice and have one phone call over a 4 week period for checkups and tests. Keep a diary of their symptoms and the number of times they use a rescue medication.

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Phase 2
      Age:18 - 65

      Key Eligibility Criteria

      Disqualifiers:Glaucoma, Daily Headaches, Others
      Must Not Be Taking:Opioids, Barbiturates, Triptans, Ergots

      72 Participants Needed

      Why Other Patients Applied

      "I changed my diet in 2020 and I’ve lost 95 pounds from my highest weight (283). I am 5’3”, female, and now 188. I still have a 33 BMI. I've been doing research on alternative approaches to continue my progress, which brought me here to consider clinical trials."

      WR
      Obesity PatientAge: 58

      "As a healthy volunteer, I like to participate in as many trials as I'm able to. It's a good way to help research and earn money."

      IZ
      Healthy Volunteer PatientAge: 38

      "I've been struggling with ADHD and anxiety since I was 9 years old. I'm currently 30. I really don't like how numb the medications make me feel. And especially now, that I've lost my grandma and my aunt 8 days apart, my anxiety has been even worse. So I'm trying to find something new."

      FF
      ADHD PatientAge: 31

      "My orthopedist recommended a half replacement of my right knee. I have had both hips replaced. Currently have arthritis in knee, shoulder, and thumb. I want to avoid surgery, and I'm open-minded about trying a trial before using surgery as a last resort."

      HZ
      Arthritis PatientAge: 78

      "I've tried several different SSRIs over the past 23 years with no luck. Some of these new treatments seem interesting... haven't tried anything like them before. I really hope that one could work."

      ZS
      Depression PatientAge: 51
      Match to a Migraine Trial
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      Why We Started Power

      We started Power when my dad was diagnosed with multiple myeloma, and I struggled to help him access the latest immunotherapy. Hopefully Power makes it simpler for you to explore promising new treatments, during what is probably a difficult time.

      Bask
      Bask GillCEO at Power
      Learn More About Trials
      How Do Clinical Trials Work?Are Clinical Trials Safe?What Can I Expect During a Clinical Trial?
      Match to a Trial
      Match to a Trial

      Frequently Asked Questions

      How much do Migraine clinical trials pay?

      Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range for Phase 2–4 trials (Phase 1 trials often pay substantially more). Further, most trials will cover the costs of a travel to-and-from the clinic.

      How do Migraine clinical trials work?

      After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll be sorted into one of the treatment groups, and receive your study drug. For some trials, there is a chance you'll receive a placebo. Across Migraine trials 30% of clinical trials have a placebo. Typically, you'll be required to check-in with the clinic every month or so. The average trial length for Migraine is 12 months.

      How do I participate in a study as a "healthy volunteer"?

      Not all studies recruit healthy volunteers: usually, Phase 1 studies do. Participating as a healthy volunteer means you will go to a research facility several times over a few days or weeks to receive a dose of either the test treatment or a "placebo," which is a harmless substance that helps researchers compare results. You will have routine tests during these visits, and you'll be compensated for your time and travel, with the number of appointments and details varying by study.

      What does the "phase" of a clinical trial mean?

      The phase of a trial reveals what stage the drug is in to get approval for a specific condition. Phase 1 trials are the trials to collect safety data in humans. Phase 2 trials are those where the drug has some data showing safety in humans, but where further human data is needed on drug effectiveness. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. As a general rule, Phase 3 trials are more promising than Phase 2, and Phase 2 trials are more promising than phase 1.

      Do I need to be insured to participate in a Migraine medical study?

      Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.

      What are the newest Migraine clinical trials?

      Most recently, we added Xeomin Injections for Migraine, Xeomin for Migraine and Migraine Preventive Medications for Migraine to the Power online platform.

      What are the current treatments for migraines?

      Migraine care has two parts: 1) fast-acting medicines for an attack, which range from simple pain relievers to triptans, newer CGRP blockers (ubrogepant, rimegepant), the ditan lasmiditan, ergotamine/DHE, and even handheld nerve-stimulation devices; and 2) preventive strategies taken regularly—beta-blockers, anti-seizure or antidepressant drugs, CGRP monoclonal-antibody injections, atogepant tablets, Botox, plus consistent sleep, exercise and trigger management—to cut down how often headaches occur. Doctors match these tools to your migraine frequency, other health conditions and side-effect risks, and will step up to preventive therapy if you still have about four or more disabling headache days per month.

      What is the root cause of migraine?

      Migraine starts with an inherited “hyper-excitable” brain network—particularly in the brain-stem and trigeminal pain pathways—that can be set off by waves of nerve activity (called cortical spreading depression) and the release of pain chemicals like CGRP. Hormone shifts, lack of sleep, certain foods, or stress don’t create the disease; they simply lower the threshold and provoke attacks in someone who already has this biological vulnerability. Knowing this helps you focus on both preventive medicines that calm those brain pathways and lifestyle steps that avoid personal triggers.

      What is a chronic migraine that won't go away?

      Chronic migraine means you suffer headaches on 15 or more days each month for at least three months, with at least eight of those days having typical migraine features; it is a long-term pattern, not a single marathon attack (that latter problem is called status migrainosus). The condition is usually tackled by limiting trigger factors and medication-overuse while starting a preventive treatment—such as daily oral drugs, periodic Botox injections, or the newer once-monthly CGRP antibody shots—under the guidance of a neurologist or headache specialist. Seek urgent care if any single attack lasts beyond 72 hours or suddenly feels different, as that could signal status migrainosus or another emergency.

      Does drinking electrolytes help with migraines?

      Electrolyte drinks are useful mainly when a migraine is brought on by dehydration—replacing both water and minerals can shorten or stop those attacks. Research shows only magnesium (about 400–600 mg a day) has real preventive benefit; extra sodium or potassium hasn’t been proven helpful and can be risky if you have heart, kidney or blood-pressure issues. Aim for steady daily hydration, use an electrolyte solution after heavy sweating or illness, and check with your doctor before taking regular magnesium or high-salt products.

      What are the 5 C's of migraines?

      The “5 C’s” are five foods and drinks that some people notice can spark a migraine: cheese, chocolate, coffee, cola (or other caffeinated soft drinks), and citrus fruits. They are only possible triggers—each one bothers certain individuals because of ingredients like tyramine or caffeine—so the practical way to find out if they affect you is to log what you eat and when headaches start, then review that pattern with your healthcare provider before cutting anything out.

      Do migraines get worse with age?

      For most people migraines are worst in their 20s-40s and slowly ease after about age 50, particularly once the hormonal ups-and-downs of perimenopause settle. That said, attacks can flare at any age if triggers pile up—hormone shifts, stress, poor sleep, or frequent use of pain relievers—so a new or noticeably different headache pattern after 50 deserves a medical check-up to rule out other causes. Keeping a trigger diary, limiting acute medicines, and asking your clinician about modern preventives (from CGRP blockers to lifestyle coaching) can stop migraines from feeling “worse with age.”

      Why can't we cure migraines?

      Migraine isn’t one simple defect but a tangle of many factors—dozens of genes, changing hormones, brain-wave events like “cortical spreading depression,” and pain chemicals such as CGRP—so blocking a single switch can’t cure every patient without also risking side-effects. Instead, doctors manage it by combining quick-relief drugs (triptans, newer CGRP blockers) with preventives (CGRP antibodies, beta-blockers, Botox, nerve-stimulation devices) while researchers keep mapping the circuitry to design even more targeted fixes. In short: we can’t yet erase migraine for everyone, but understanding is growing fast and today’s tailored treatments already let many people live nearly attack-free.

      What are G pants for migraines?

      “G-pants” is a nickname for “gepants,” a new group of oral (and one nasal-spray) migraine drugs—ubrogepant, rimegepant, atogepant and zavegepant—that block the CGRP receptor, a chemical switch that helps trigger migraine pain. Taken either at the start of an attack (ubrogepant, rimegepant, zavegepant) or once daily/every other day to cut the number of attacks (atogepant, rimegepant), they offer relief without the blood-vessel-tightening risk of older triptans; the most typical side-effects are mild nausea, fatigue or taste changes. Ask your doctor whether gepants fit your situation, especially if you have heart-disease risks or haven’t done well on triptans.

      How do you break a chronic migraine?

      Think of it in two steps. 1) If a migraine has dragged on for 3-plus days, a headache specialist can “break” it with short-term measures such as a triptan or NSAID taken early, a brief oral steroid taper, or in clinic/ER infusions like dihydroergotamine, IV metoclopramide, or a newer “gepant” pill; these reset the attack without causing medication-overuse headache. 2) To keep it from becoming chronic again, you need daily prevention tailored to you—common options are onabotulinumtoxinA shots or once-monthly CGRP-antibody injections, strict trigger and sleep hygiene, and limiting pain pills to <10 days a month—reviewed every few months with a headache specialist.

      What toxin is used for migraines?

      Doctors use onabotulinumtoxinA, best known by the brand name Botox, to prevent chronic migraine—defined as at least 15 headache days a month—when standard preventive medicines haven’t helped. Every 12 weeks a neurologist injects tiny amounts into about 31 spots across the scalp, forehead, and neck; this can cut monthly headache days by roughly 7-9 days, with the most common side-effects being temporary neck pain or mild eyelid droop. Ask your headache specialist whether you meet the criteria and whether any other medical conditions or medications would make this treatment unsuitable for you.