Truncal Vagotomy for Acid Reflux
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether truncal vagotomy, a surgical procedure, can reduce acid reflux (heartburn) after certain weight loss surgeries. Some participants will undergo this procedure during their surgery, while others will not. The trial aims to determine if the procedure affects the management of gastroesophageal reflux disease (GERD) symptoms. Individuals undergoing a sleeve to bypass revision surgery who regularly experience acid reflux might be suitable candidates for this trial. As an unphased trial, it offers participants the chance to contribute to innovative research that could enhance GERD management following weight loss surgery.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that truncal vagotomy is safe for reducing GERD post-surgery?
Research has shown that truncal vagotomy, a surgery involving the cutting of the vagus nerve to reduce stomach acid, has long been used to treat peptic ulcer disease (PUD). This surgery was once the primary treatment for PUD. Historical data indicates that truncal vagotomy was widely used and generally safe.
However, some studies report a risk of accidental nerve damage during the surgery, occurring in 10% to 42% of cases. These injuries usually did not significantly affect acid reflux outcomes, but they are important to consider. Overall, despite the risks, the procedure's common use in the past suggests it is relatively safe.12345Why are researchers excited about this trial?
Truncal vagotomy is unique because it targets acid reflux by cutting the vagus nerve, which reduces stomach acid production. This is different from standard treatments like proton pump inhibitors or H2 blockers, which primarily work by blocking acid production through medication. Researchers are excited about truncal vagotomy because it offers a surgical solution that might provide long-term relief for patients who haven't responded well to typical medications. Additionally, this approach could potentially reduce the need for lifelong medication use, offering a different pathway to manage acid reflux effectively.
What evidence suggests that truncal vagotomy might be an effective treatment for GERD?
Research has shown that truncal vagotomy, a surgery that cuts parts of a nerve in the stomach, can help lower stomach acid. This reduction in acid can alleviate symptoms of gastroesophageal reflux disease (GERD). Truncal vagotomy has been studied for its effectiveness in treating ulcers and reducing acid levels. Evidence suggests it might also help manage acid reflux. Studies have found that it can decrease the recurrence of acid-related issues. This trial will compare truncal vagotomy, performed during other routine procedures, with no truncal vagotomy to evaluate its effectiveness in easing GERD symptoms, especially when other surgeries have not succeeded.12678
Are You a Good Fit for This Trial?
This trial is for adults over 18 who are eligible for a specific weight loss surgery, changing from sleeve gastrectomy to gastric bypass. It's not open to those who don't meet the surgical criteria.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Surgery and Treatment
Participants undergo truncal vagotomy along with sleeve to bypass revision surgery
Follow-up
Participants are monitored for GERD severity and incidence post-surgery
What Are the Treatments Tested in This Trial?
Interventions
- Truncal vagotomy
Find a Clinic Near You
Who Is Running the Clinical Trial?
Baylor Research Institute
Lead Sponsor