Rice and Beans + Exercise for Muscle Health

(CompProtein Trial)

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Overseen ByNicholas A Burd (Associate Professor), PhD
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: University of Illinois at Urbana-Champaign
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to explore how rice and beans affect muscle health compared to isolated nutrients after exercise. Researchers seek to understand how these foods influence amino acid levels and muscle protein growth. Participants will consume both meals after workouts to determine which more effectively boosts muscle health. Ideal candidates are healthy, active adults aged 20 to 35 who have maintained a stable weight for the past six months. As an unphased trial, participants can contribute to groundbreaking research on nutrition and exercise.

Will I have to stop taking my current medications?

The trial requires that you stop taking certain medications, especially those affecting protein metabolism, endocrine function, or muscle mass, such as prescription-strength corticosteroids, non-steroidal anti-inflammatories, and certain dietary supplements, at least 6 weeks before participation.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that rice and beans are generally safe and easy to digest. They provide protein and fiber, aiding muscle recovery after exercise. Studies also indicate that plant-based proteins, like those in rice and beans, support muscle health and overall well-being when part of a well-planned diet.

The trial includes basic nutrients similar to those in a rice and beans meal. These nutrients include amino acids (components of proteins) and carbohydrates, resembling everyday foods and safe in the trial's amounts.

Overall, both rice and beans and these basic nutrients are considered safe for supporting muscle health when included in a balanced diet.12345

Why are researchers excited about this trial?

Researchers are excited about the Rice and Beans + Exercise treatment for muscle health because it leverages a whole-food approach, providing a balanced mix of protein, carbohydrates, and minimal fat in a natural form. Unlike standard protein supplements or isolated nutrient drinks, this treatment uses a complete meal of rice and black beans, which may offer additional benefits like fiber and phytonutrients found in whole foods. This approach could potentially enhance muscle recovery and growth following exercise, offering a more holistic and accessible alternative to traditional supplementation.

What evidence suggests that this trial's treatments could be effective for muscle health?

This trial will compare the effects of a rice and beans meal with isolated nutrients on muscle health. Research has shown that eating rice and beans together provides a complete protein, as rice supplies the nutrients that beans lack, and vice versa. This combination offers all the essential components needed for muscle growth. In one study with mice, a similar diet improved muscle mass and strength. Although this does not directly prove the same effect in humans, it suggests that this combination could enhance muscle health.16789

Are You a Good Fit for This Trial?

This trial is for young, healthy adults aged 20-35 who are interested in how plant-based foods affect muscle building after exercise. Participants should be willing to undergo resistance exercise and have blood and muscle samples taken.

Inclusion Criteria

Recreationally-active
I have not gone through menopause.
Weight stable for prior 6 months
See 1 more

Exclusion Criteria

I am not between the ages of 20 and 35.
Pregnancy
Irregular menstrual cycles (i.e., ~21 day or ~35 day cycle)
See 24 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Preliminary Testing

Participants undergo anthropometrics, resting metabolic rate testing, 10-repetition maximum testing, and habitual diet recording

1 day
1 visit (in-person)

Infusion Trials

Participants receive stable isotope tracer infusions, perform resistance exercise, and ingest meals for analysis of protein synthesis rates

2 sessions, at least 7 days apart
2 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after infusion trials

1 week

What Are the Treatments Tested in This Trial?

Interventions

  • Isolated Mixture
  • Resistance Exercise
  • Rice and Beans
Trial Overview The study tests whether eating rice and beans or just their basic nutrients (like amino acids) right after a workout affects muscle growth differently. Each participant will try both methods in separate sessions to compare results.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: Rice and Beans (COMP)Experimental Treatment2 Interventions
Group II: Isolated Nutrients (ISO)Active Control2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Illinois at Urbana-Champaign

Lead Sponsor

Trials
203
Recruited
40,600+

Published Research Related to This Trial

In a study involving ovariectomized mice on a high-fat diet, rice bran supplementation improved muscle mass and strength while reducing markers of muscle atrophy, indicating its potential to combat obesity-related muscle loss.
Rice bran also enhanced gut health by increasing the expression of tight junction proteins and promoting beneficial gut bacteria, suggesting it may help restore gut microbiota balance in estrogen-deficient conditions.
Rice Bran Supplementation Ameliorates Gut Dysbiosis and Muscle Atrophy in Ovariectomized Mice Fed with a High-Fat Diet.Huang, PX., Yeh, CL., Yang, SC., et al.[2023]
Germinated brown rice (GBR) and brown rice (BRR) significantly reduced high-fat diet-induced increases in fasting plasma glucose, lipids, insulin resistance, and inflammation in mice, compared to white rice (WHR).
GBR specifically increased the abundance of beneficial gut bacteria, Lactobacillus gasseri, and improved metabolic health, suggesting that GBR may have unique probiotic effects not seen with BRR or WHR.
Impact of Germinated Brown Rice and Brown Rice on Metabolism, Inflammation, and Gut Microbiome in High Fat Diet-Induced Insulin Resistant Mice.Zhao, R., Huang, F., Liu, C., et al.[2022]
In a study involving 59 volunteers, 30 days of soy protein supplementation significantly increased skeletal muscle volume in individuals with low physical activity compared to casein protein supplementation.
For bedridden patients, both soy and casein protein increased muscle volume, but soy protein led to greater improvements in knee extension strength, suggesting it may be particularly effective in preventing muscle atrophy due to immobilization.
Effects of dietary soy protein on skeletal muscle volume and strength in humans with various physical activities.Hashimoto, R., Sakai, A., Murayama, M., et al.[2019]

Citations

Rice and Beans + Exercise for Muscle Health ...In a study involving ovariectomized mice on a high-fat diet, rice bran supplementation improved muscle mass and strength while reducing markers of muscle ...
The association of dietary patterns with muscle mass and ...Higher oDPS on a dietary pattern predominantly rich in fish, vegetables, nuts and seeds, fruit and berries, and eggs was associated with better ASMM at age 67– ...
How Much Protein Do I Need To Build Muscle?An example is combining rice and beans: The amino acids missing from beans are found in rice and vice versa. These proteins don't have to be ...
Are plant-based and omnivorous diets the same for muscle ...This narrative review examines the potential challenges associated with plant-based diets in supporting muscle hypertrophy among resistance-trained athletes.
How Much Protein Do You Need to Build Muscle?Grains like rice are low in an amino acid called lysine, whereas legumes like beans are high in lysine but low in methionine and cysteine.
Achieving Optimal Post-Exercise Muscle Protein ...This review aims to evaluate the efficacy of the ingestion of nutrient-rich and protein-dense whole foods to support post-exercise muscle protein remodeling ...
Effect of Plant-Based Proteins on Recovery from ...With appropriate planning and guidance, plant-based protein intake can be both nutritionally adequate and safe for supporting muscle recovery and overall health ...
8 Foods to Protect Your Muscles as You AgeMediterranean and Japanese diets may offer protection from sarcopenia because they're low in fat while being high in vegetables, fruits and high ...
Runner's DietRunners should eat fruits, vegetables, lean protein, healthy fats, and carbs, with 60-70% calories from carbs, and 15-20% each from protein and fat. Avoid low ...
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