Direct Current Stimulation for Stroke

This trial investigates how direct current stimulation, a type of electrical therapy, might improve walking for individuals who have had a stroke and continue to struggle with mobility. The research aims to identify which brain and nerve pathways influence leg coordination and how this affects walking abilities. Participants will receive electrical stimulation in various body areas to determine its impact on leg coordination and walking. Individuals who have experienced a stroke affecting one side of the brain and can walk for at least six minutes may be suitable candidates for this trial. As an unphased trial, this study offers participants the opportunity to contribute to groundbreaking research that could enhance stroke recovery therapies.

The trial does not specify if you need to stop taking your current medications, but you cannot participate if you use medications that could increase the risk of seizures.

Research has shown that the type of direct current stimulation used in this trial is generally safe for stroke patients. Studies have found that brain stimulation with up to 4 mA is safe and well-tolerated, with most people experiencing only mild side effects, such as tingling.

Similar safety has been observed for spinal stimulation. A small number of people report mild side effects like itching or burning.

For sensory stimulation, findings are consistent. This stimulation, applied to the brain's motor area, has been used safely, with some people experiencing mild sensations like tingling or itching. Serious side effects are rare in these studies.

Researchers are excited about these direct current stimulation treatments for stroke because they offer a novel approach to neurorehabilitation. Unlike standard treatments like physical therapy or medication, direct current stimulation directly targets neural pathways to potentially enhance recovery. The supraspinal, spinal, and sensory methods each have unique applications: supraspinal stimulation targets motor cortex areas, spinal stimulation focuses on the spine and shoulder, and sensory stimulation engages the superficial peroneal nerve. This diversity in targeting specific neural regions could lead to more tailored and effective stroke rehabilitation strategies.

This trial will compare different methods of direct current stimulation (DCS) for stroke recovery. Research has shown that DCS can improve movement after a stroke. In this trial, participants may receive supraspinal DCS, applied to the brain, which studies have found to positively affect leg movement, aiding in walking and balance. Another group will receive spinal DCS, which might improve movement by helping the brain adapt and change. Additionally, some participants will receive sensory DCS, which, when used with regular rehabilitation, has been shown to enhance recovery, improving movement and daily activities. While results can differ, these findings suggest DCS could be a promising treatment for walking difficulties after a stroke.³⁶⁷⁸⁹