Circulation Evaluation Techniques for Sepsis

(DAISY Trial)

This trial examines new methods to predict outcomes for patients with sepsis, a serious condition resulting from the body's response to infection. Researchers use tools like sublingual microscopy (a small camera to examine under the tongue) and urine tests to study blood flow and cell health. Participants include patients with sepsis and individuals undergoing surgery with general anesthesia. Those battling sepsis or preparing for surgery might be eligible to join. As an unphased trial, this study provides a unique opportunity to contribute to groundbreaking research that could enhance future sepsis care.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research shows that the treatments in this study are generally safe and well-tolerated. Studies have found that Microscan Sublingual Microscopy is a safe and practical method for checking blood flow under the tongue in emergencies, unlikely to cause harm or discomfort to patients.

The Starling SV-Passive Leg Raise is another technique being tested. Research suggests that this method safely and effectively assesses how well the heart pumps blood, helping doctors determine the heart's response to fluids without risking patient safety.

For the Vexus Ultrasound Scoring, research has shown that using ultrasound to check blood flow and congestion does not cause serious side effects. It is considered a safe way to evaluate fluid levels in patients with sepsis.

Researchers are excited about this trial because it explores new ways to evaluate sepsis, a serious condition that currently relies heavily on standard methods like blood tests and clinical assessments. One of the unique aspects of this trial is the use of Microscan Sublingual Microscopy, which provides a close look at blood flow under the tongue, potentially offering earlier and more precise detection of circulatory issues. Additionally, the Starling SV Passive Leg Raise technique could give a better understanding of fluid responsiveness, which is crucial for managing sepsis patients effectively. By combining these innovative techniques with traditional urine collection and Vexus Ultrasound Scoring, this trial aims to enhance our understanding of sepsis and improve patient outcomes through more accurate and timely assessments.

This trial will compare different techniques for evaluating circulation in sepsis. Research has shown that examining blood flow in tiny vessels under the tongue, a method used in the trial's Microscan Sublingual Microscopy intervention, provides important information about sepsis. Poor blood flow in these small vessels often links to worse outcomes in sepsis patients. The Starling SV-Passive Leg Raise test, another intervention in this trial, helps doctors assess fluid levels and heart function during sepsis, guiding treatment and potentially improving patient outcomes. Vexus ultrasound scoring, also part of this trial, is a promising tool for managing fluid levels, though its ability to predict serious issues like kidney damage or death has shown mixed results. Overall, these tools offer valuable insights into managing sepsis, but more research is needed to fully understand their effectiveness.²³⁴⁶⁷