Exercise Program for Restless Legs Syndrome

(PEARLS Trial)

This trial explores how exercise affects molecules in the blood of people with restless legs syndrome (RLS) to better understand the condition. Researchers compare the impact of a 12-week RLS exercise program with no exercise on blood proteins. Participants will be randomly assigned to either exercise regularly or not exercise at all for 12 weeks, with blood samples taken before and after the trial. People with moderate-to-severe RLS who aren't currently active or receiving treatment might be a good fit.

As an unphased trial, this study offers a unique opportunity to contribute to foundational research that could lead to new insights and treatments for RLS.

The trial does not specify whether you need to stop taking your current medications, but it requires that participants have untreated restless legs syndrome (RLS). This suggests that you should not be on any current treatment for RLS to participate.

Research has shown that exercise is generally safe for people with Restless Legs Syndrome (RLS). In past studies, various types of exercise, such as yoga and strength training, have been tested with individuals who have RLS. These studies found that exercise can safely help reduce RLS symptoms. Specifically, one study found that a 12-week exercise program was safe when combined with RLS medication.

Researchers are excited about this exercise program for Restless Legs Syndrome (RLS) because it offers a non-pharmaceutical approach to managing symptoms. Unlike standard treatments like medications that often target neurotransmitters, this program focuses on physical activity, which can enhance overall well-being and potentially reduce symptoms through improved circulation and muscle conditioning. The program combines strength training, cardiovascular exercise, and stretching specifically tailored for RLS, offering a holistic way to address the condition. This approach might appeal to those seeking alternatives to medication-related side effects or those who prefer lifestyle modifications.

Research has shown that exercise can help people with restless legs syndrome (RLS). In this trial, participants in the exercise arm will complete a 12-week RLS-specific exercise program. Studies have found that such a program can greatly reduce RLS symptoms. For example, one study reported a clear decrease in symptom severity after participants finished the 12-week exercise routine. Another study observed better mood and lower stress levels, which are often connected to RLS symptoms. Overall, exercise seems to help manage RLS by lessening symptoms and boosting overall well-being.¹²⁵⁶⁷