SRP + MM for Gum Disease

This trial explores the effectiveness of minocycline microspheres (tiny antibiotic particles) combined with scaling and root planing (deep cleaning) for gum disease. Researchers compare this combination to deep cleaning alone and to individuals with healthy gums. It targets those with gum disease, specifically periodontitis, and at least 20 natural teeth. Recent dental cleanings, smoking, or certain medications may disqualify participation. As an unphased trial, this study provides a unique opportunity to contribute to understanding new treatment combinations for gum disease.

Yes, you may need to stop taking certain medications, especially if they affect gum disease, are non-steroidal anti-inflammatory drugs, or are antibiotics. The trial excludes participants currently using these medications.

Research has shown that using minocycline microspheres (MM) with scaling and root planing (SRP) is safe for patients. This combination reduces gum disease symptoms more effectively than SRP alone. After one month, patients who received both MM and SRP showed a greater decrease in gum pocket depth, a sign of gum disease, compared to those who did not use MM.

Researchers are excited about the combination treatment of Scaling and Root Planing (SRP) with minocycline microspheres (MM) for gum disease because it offers a novel approach to managing the condition. Unlike traditional treatments, which mainly involve mechanical cleaning through SRP, this approach introduces minocycline, an antibiotic, directly into the gums via microspheres. This targeted delivery system not only enhances the effectiveness of the treatment by directly combating bacteria at the site of infection but also potentially reduces the need for systemic antibiotics, minimizing side effects. This innovative combination could lead to more effective and efficient periodontal care.

Research has shown that using minocycline microspheres (MM) with scaling and root planing (SRP) can improve gum health. In this trial, one group of participants will receive SRP alone, while another group will receive SRP combined with MM. Studies have found that adding MM to SRP leads to a greater reduction in pocket depth, an important sign of gum disease. Specifically, one study found that patients who received this combination treatment healed better than those who only had SRP. Additionally, large studies in real-world settings have confirmed that SRP with MM effectively manages gum disease. These findings suggest that adding MM to SRP could be a promising way to treat gum disease.³⁵⁶⁷⁸