Nutritional Supplements for Knee Surgery Recovery

This trial explores whether omega-3 fatty acids and essential amino acids (EAAs) can reduce muscle loss after knee surgery. It seeks to determine if this nutritional approach could serve as an alternative to exercises and drugs for those recovering from anterior cruciate ligament (ACL) surgery. Participants will receive either the nutritional supplements or a placebo to assess differences in muscle strength and recovery. Individuals with an ACL injury scheduled for surgery in Kingston, ON, who are not currently taking fish oils or steroids, may be suitable for this study. As an unphased trial, it offers participants the opportunity to contribute to innovative research that could enhance recovery options for future patients.

The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are currently taking fish oils, steroids, or certain blood thinners. It's best to discuss your specific medications with the trial team.

Research shows that omega-3 fatty acids and essential amino acids (EAAs) can help prevent muscle loss by supporting muscle growth. Studies have found these nutrients to be generally safe and well-tolerated in healthy individuals. When taken as supplements, omega-3 fatty acids have been linked to improved muscle strength and size.

Omega-3 fatty acids are usually safe at research doses, though some people might experience mild side effects like an upset stomach or a fishy aftertaste. EAAs are also safe for most individuals and are a normal part of the diet, aiding in protein building.

Researchers are excited about using omega-3 fatty acids and essential amino acids for knee surgery recovery because these supplements target inflammation and muscle repair, unlike traditional pain medications and physical therapy. Omega-3s, particularly EPA and DHA, are known for their anti-inflammatory properties, which can help reduce swelling and pain post-surgery. Essential amino acids (EAAs) support muscle protein synthesis, potentially speeding up recovery and improving muscle strength. This dual approach addresses both inflammation and muscle healing, offering a comprehensive alternative to conventional treatments.

This trial will compare the effects of a nutritional intervention with a placebo control on knee surgery recovery. Participants in the nutritional intervention arm will receive omega-3 fatty acids and essential amino acids (EAAs). Studies have shown that EAAs and omega-3 fatty acids can each help slow muscle loss in healthy individuals. Research indicates that taking EAAs before and after knee surgery can reduce muscle loss and aid recovery. Omega-3s have also been found to lessen arthritis pain and protect joints, potentially aiding recovery. Although specific data on using these supplements together for surgery recovery is not yet available, their individual benefits suggest they might work well together to help maintain muscle after surgery.¹⁶⁷⁸⁹