Laser Resurfacing for Precancerous Skin Lesions

This trial aims to determine if Fractionated Laser Resurfacing can protect the forearm and wrist skin from precancerous spots known as actinic keratosis (AKs) and help prevent skin cancer. Researchers are also investigating whether skin photos can predict where these spots might develop. The trial involves treating each forearm separately with the laser. Ideal participants are individuals aged 60 or older with 5 to 10 AKs on each forearm, fair skin, and no large tattoos or recent skin treatments on their forearms. As an unphased trial, this study offers participants the chance to contribute to innovative research that could lead to new preventive measures for skin cancer.

The trial protocol does not specify whether you need to stop taking your current medications. However, if you are on systemic hormone replacement therapy, you cannot participate in the trial.

Research shows that Fractionated Laser Resurfacing (FLR) improves skin issues such as sun damage, scars, and wrinkles. Studies have found that it treats only part of the skin’s surface, aiding healing and shortening recovery time.

Patients generally tolerate FLR well. Common side effects include redness, swelling, and a sensation similar to a sunburn immediately after treatment. These effects typically disappear within a few days. Reports of serious side effects are rare. However, individual reactions can vary.

Fractionated Laser Resurfacing is unique because it offers a non-invasive way to treat precancerous skin lesions by using laser technology to precisely target affected areas. Unlike traditional treatments like topical creams or surgical excision, this method reduces damage to surrounding healthy skin and may minimize recovery time. Researchers are excited because it could provide a more efficient and less painful alternative with potentially fewer side effects.

Research has shown that Fractionated Laser Resurfacing (FLR) effectively removes precancerous skin spots, such as actinic keratosis (AKs), potentially preventing skin cancer. Studies have found that this laser treatment clears sun-damaged skin, making it appear smoother and healthier. FLR targets and removes damaged skin cells, reducing the risk of developing skin cancers like squamous cell carcinoma and basal cell carcinoma. Additionally, this treatment improves skin texture and reduces signs of aging, such as wrinkles and sun spots. These benefits suggest that FLR could be a promising option for individuals with precancerous skin conditions. In this trial, participants will receive FLR treatment on either their right or left forearm to assess its effectiveness.²⁴⁶⁷⁸