Mosaic Embryo Transfer for Infertility
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to evaluate the effectiveness of transferring a mosaic embryo (an embryo with both normal and abnormal cells) for women facing infertility. It focuses on those who have already undergone in vitro fertilization (IVF) with genetic testing at the Colorado Center for Reproductive Medicine. Women who have completed this process and have a mosaic embryo ready for transfer may be suitable candidates. The trial will assess the outcomes of transferring a single mosaic embryo to the uterus. As an unphased trial, this study provides a unique opportunity to contribute to pioneering research in reproductive medicine.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What prior data suggests that Mosaic Embryo Transfer is safe for infertility treatment?
Research has shown that using mosaic embryos, which contain a mix of normal and abnormal cells, does not increase the risk of birth defects. Recent evidence suggests that this process is safe for birth outcomes. However, the likelihood of pregnancy is lower with these embryos compared to those without mosaicism. Studies indicate that embryos with a high level of mosaicism have an even lower chance of implanting in the womb and leading to pregnancy.
In summary, while mosaic embryos do not raise the risk of birth defects, they are less likely to result in pregnancy. These factors are important to consider when deciding to participate in a study involving mosaic embryo transfer.12345Why are researchers excited about this trial?
Mosaic Embryo Transfer is unique because it offers a new option for women undergoing IVF by utilizing embryos with a mix of normal and abnormal cells, known as mosaic embryos. Unlike traditional IVF, which generally selects only embryos with entirely normal cells for transfer, this approach opens the door for potentially viable embryos that might otherwise be discarded. Researchers are excited about this method because it could increase the chances of pregnancy for women who have limited embryos available, providing new hope for those struggling with infertility.
What evidence suggests that Mosaic Embryo Transfer might be an effective treatment for infertility?
Research has shown that transferring mosaic embryos, a procedure participants in this trial will undergo, can lead to successful pregnancies. One study found that 40.1% of these embryos implanted successfully. Other studies have found that up to 30% of mosaic embryo transfers result in healthy births, although there is a 20% chance of miscarriage. Embryos with fewer chromosomal issues have a better chance of success. These findings suggest that mosaic embryo transfer can be a promising option for some people trying to conceive, despite the risks.12567
Who Is on the Research Team?
Mandy Katz-Jaffe, PhD
Principal Investigator
Fertility Genetics
Are You a Good Fit for This Trial?
This trial is for women aged 18-45 who are infertile and have completed an IVF cycle with PGT at CCRM, possessing a mosaic embryo. They must be willing to transfer only one embryo and meet the clinic's standards for an embryo transfer. It excludes those desiring multiple embryos, using gestational carriers, or having certain chromosomal errors.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Transfer of a mosaic embryo to the uterus after in vitro fertilization with preimplantation genetic testing
Follow-up
Participants are monitored for implantation and live birth rates, as well as miscarriage and stillbirth rates
Neonatal Outcomes
Assessment of the health of the infant, noting any medical problems
What Are the Treatments Tested in This Trial?
Interventions
- Mosaic Embryo Transfer
Mosaic Embryo Transfer is already approved in European Union, United States, Canada, Japan, China, Switzerland for the following indications:
- Infertility treatment for individuals lacking euploid embryos
- Infertility treatment for individuals lacking euploid embryos
- Infertility treatment for individuals lacking euploid embryos
- Infertility treatment for individuals lacking euploid embryos
- Infertility treatment for individuals lacking euploid embryos
- Infertility treatment for individuals lacking euploid embryos
Find a Clinic Near You
Who Is Running the Clinical Trial?
Colorado Center for Reproductive Medicine
Lead Sponsor