Neurobehavioral Therapy for Conversion Disorder

(NBT for mFND Trial)

This trial tests Neurobehavioral Therapy (NBT) to determine its effectiveness for individuals with motor functional neurological disorder (mFND), a condition affecting movement without an obvious physical cause. Researchers aim to discover if NBT can reduce symptoms and enhance daily functioning compared to standard medical care. Participants will either receive 12 weekly sessions of NBT alongside their usual care or continue with their usual care alone. Individuals diagnosed with mFND who have experienced symptoms in the past year may be suitable for this trial. As an unphased trial, this study provides a unique opportunity to contribute to groundbreaking research that could improve future treatments for mFND.

The trial does not specify if you need to stop taking your current medications. Participants will continue their standard medical care, so it's likely you can keep taking your current meds.

Research has shown that Neurobehavioral Therapy (NBT) is generally safe for treating functional neurological disorders. In previous studies, patients who received this therapy experienced better results without major safety issues. Although these studies focused on clinical outcomes, they did not report significant harmful side effects. This indicates that patients usually tolerate NBT well. However, consulting a healthcare professional is essential to understand what this means personally.¹²³⁴⁵

Researchers are excited about neurobehavioral therapy for conversion disorder because it offers a new approach that integrates psychological and physical treatment. Unlike standard medical care that primarily focuses on managing symptoms, this therapy empowers patients by using a structured workbook to help them regain control over their movements. The therapy is delivered through weekly virtual sessions complemented by in-person visits, providing a flexible and comprehensive support system. This innovative method aims not only to treat symptoms but also to address the underlying behavioral aspects of conversion disorder, potentially leading to more effective and lasting results.

Neurobehavioral Therapy (NBT), which participants in this trial may receive, has shown promise in treating functional neurological disorders. For instance, one study found that therapy reduced seizures in most patients. Another study demonstrated that a structured therapy approach improved outcomes for patients with motor functional neurological disorder (mFND). Additionally, an outpatient therapy program reduced anxiety, depression, and daily challenges in patients with similar conditions. These findings suggest that NBT may alleviate symptoms of mFND and enhance overall well-being.¹²⁶⁷⁸