Glycerol-Enhanced Electrolyte Beverages for Fluid Balance

This trial tests different electrolyte drinks to determine their effectiveness in maintaining fluid balance. Researchers aim to discover if adding glycerol, a specific compound, enhances hydration compared to regular drinks without it. Participants will try various drinks, some containing glycerol and some not, to compare their effects on hydration over time. The trial seeks individuals who are active at least three days a week and do not have major health issues that could interfere with the study. As an unphased trial, it offers participants the chance to contribute to innovative research on hydration solutions.

The trial requires that you do not take medications that may interfere with the study, such as diuretics (medications that help remove excess water from the body). If you are taking any medication, it's best to discuss it with the study investigator to see if it might affect your participation.

Previous studies have shown that glycerol is safe for humans. Research indicates that when glycerol is used in drinks with electrolytes, it effectively manages body fluids without causing major side effects. For example, one study found that glycerol improved fluid retention, which is important for proper hydration.

Another study found that even at higher amounts, glycerol did not cause serious health problems. Some participants experienced minor issues like mild stomach discomfort, but these were rare and typically resolved on their own.

Researchers are excited about these glycerol-enhanced electrolyte beverages because they offer a new way to improve fluid balance. Unlike typical electrolyte solutions, these beverages include glycerol, which can enhance water absorption and retention in the body. This could be especially beneficial for athletes or individuals needing to maintain hydration during intense physical activity. By altering the carbohydrate and glycerol content, the solutions could potentially optimize performance and recovery in ways current sports drinks do not.

This trial will compare various electrolyte beverages, both with and without glycerol, to assess their effectiveness in maintaining hydration. Studies have shown that adding glycerol to electrolyte drinks can enhance hydration compared to similar drinks without it. Research indicates that glycerol enables these drinks to maintain hydration effectively, even with reduced sodium. Tests with drinks containing 0%, 1%, and 6% carbohydrates plus glycerol showed they kept people better hydrated than drinks without glycerol. This suggests glycerol may help the body retain fluids more effectively, offering promise for improved hydration.¹²³⁵⁶