Brain-Training Exercises for Long COVID

This trial explores whether brain-training exercises can help older adults with Long COVID. Researchers aim to determine if these computer-based activities can enhance memory, mood, and daily functioning for individuals with ongoing cognitive issues after recovering from COVID-19. The treatment under investigation is called NeuroFlex. Suitable participants are those aged 60 or older who experience lingering cognitive symptoms after COVID-19 that impact their daily life. As an unphased trial, this study provides a unique opportunity to contribute to understanding how brain-training might aid recovery from Long COVID.

The trial requires that if you are on psychiatric medications, you must be on a stable dose for at least 1 month before starting the study and have no plans to change the dose during the study.

Research shows that computerized brain-training exercises, like those used in NeuroFlex, are generally easy for people to handle. Studies on similar activities have found they usually don't cause serious side effects. Often compared to video games, these exercises are designed to be fun and safe. Participants might experience mild issues, such as eye strain or tiredness, but these are typically temporary. Past studies with similar brain-training programs have reported no major problems. Thus, current evidence suggests that NeuroFlex is likely a safe choice for most people.¹²³⁴⁵

NeuroFlex is unique because it uses computerized cognitive remediation to tackle the lingering cognitive issues of Long COVID. Unlike traditional treatments that often focus on symptom management, like medication or physical therapy, NeuroFlex directly targets brain function through interactive brain-training exercises. Researchers are excited because this approach could enhance cognitive flexibility and memory, offering a non-invasive, engaging, and potentially more effective way to improve mental clarity and quality of life for Long COVID patients.

Research has shown that computer-based brain exercises might help older adults with Long COVID feel better. These exercises improve thinking skills like memory and focus, which Long COVID often affects. Some studies suggest that brain-training can also boost mood and overall quality of life for those with these symptoms. While specific proof for brain-training's effect on Long COVID is still developing, its success in addressing other health issues suggests it could be useful. Early results from this trial, which includes a treatment arm using Computerized Cognitive Remediation, indicate these exercises might help manage Long COVID symptoms.¹⁶⁷⁸⁹