Vaping vs. Nicotine Replacement for Smoking Behavior

This trial examines how different tools can aid smoking cessation, focusing on electronic cigarettes (ECs) compared to nicotine patches and lozenges. Researchers aim to determine if the flavor of ECs, such as tobacco or non-tobacco, influences their appeal and effectiveness in reducing smoking cravings and withdrawal symptoms. Participants will be divided into three groups to use preferred flavor ECs, tobacco flavor ECs, or nicotine replacement therapy (NRT), which includes options like nicotine gum, lozenges, patches, inhalers, and mouth spray, for 14 weeks. This study suits individuals who smoke at least 5 cigarettes a day, are open to trying either ECs or NRT, and possess a smartphone. As an unphased trial, it offers a unique opportunity to explore personalized smoking cessation options.

The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are currently using smoking cessation medications or nicotine replacement therapy.

A previous study showed that vaping can help people quit smoking with fewer serious side effects than regular cigarettes. Research indicates that the risk of death or major health problems from vaping is low. However, vaping carries some risks, such as nicotine addiction, lung irritation, and other health issues, though these are usually less severe than those from smoking.

For nicotine replacement therapy (NRT), such as patches and lozenges, safety has been well-proven. The FDA has approved NRT to help people quit smoking, and it is known to be safe for most users.

Researchers are excited about this trial because it compares vaping with nicotine replacement therapy (NRT) in helping people quit smoking. Unlike traditional methods like nicotine patches and lozenges, vaping in this context might offer a different psychological and behavioral experience that could make quitting easier for some. The trial also includes a unique educational component, where participants engage in discussions, potentially boosting success rates by addressing the social and habitual aspects of smoking. By exploring these different approaches, researchers aim to understand which method is more effective, offering new insights into smoking cessation strategies.

This trial will compare the effectiveness of e-cigarettes and nicotine replacement therapy (NRT) in helping people quit smoking. Studies have shown that e-cigarettes can help people quit smoking more effectively than nicotine patches or gum, especially when combined with support from a counselor or support group. Research indicates that e-cigarettes, whether flavored like tobacco or not, can help reduce the urge to smoke and ease withdrawal symptoms. They also seem to boost motivation and confidence to quit smoking. While some studies suggest e-cigarettes might not work for everyone, they generally seem to be a helpful tool for many smokers. Overall, e-cigarettes show promise as a way to help people stop smoking, with flavored options possibly making them more appealing and effective. Participants in this trial will receive either e-cigarettes or NRT in different arms to evaluate their effectiveness.¹⁴⁶⁷⁸