High Flow Nasal Therapy for COPD
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial examines the effectiveness of a device called myAirvo 3, a high-flow nasal therapy device, for individuals with moderate to very severe COPD, a lung condition that makes breathing difficult. Participants will either use this device alongside their usual COPD care or continue with their regular care. The researchers aim to determine if myAirvo 3 can reduce serious flare-ups that often require hospital visits. Suitable candidates have experienced COPD flare-ups needing hospitalization in the last six weeks and are willing to use the device daily at home. As an unphased trial, this study provides a unique opportunity to enhance understanding of how myAirvo 3 can improve COPD management.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. It seems you can continue your usual COPD medical care while participating.
What prior data suggests that High Flow Nasal Therapy is safe for COPD patients?
Research has shown that the myAirvo 3 device, used for High Flow Nasal Therapy (HFNT), is generally safe for people with long-term breathing problems. This device delivers warm and moist air or oxygen through a special nasal tube. Studies have found that individuals with chronic breathing issues tolerate this therapy well at home. No major reports of serious side effects have emerged. However, like any medical treatment, some individuals might experience mild discomfort or irritation from the nasal tube. Overall, evidence suggests that myAirvo 3 is a safe choice for patients with moderate to very severe COPD.12345
Why are researchers excited about this trial?
Researchers are excited about myAirvo 3 for COPD because it offers a unique approach with its integrated humidifier and flow generator. Unlike standard treatments that might focus on medications or inhalers, myAirvo 3 delivers high-flow oxygen therapy directly through a nasal cannula, which can provide consistent, comfortable respiratory support. This method may improve patient outcomes by enhancing oxygen delivery and maintaining airway humidity, potentially leading to better management of symptoms and improved quality of life for those with COPD.
What evidence suggests that High Flow Nasal Therapy is effective for COPD?
Studies have shown that High Flow Nasal Therapy (HFNT) using the myAirvo 3 device can help people with COPD breathe more easily. In this trial, one group of participants will receive usual COPD care with the myAirvo 3 integrated humidifier and flow generator. Research suggests that using this device at home might lower the risk of hospital readmission for COPD symptoms. Patients using HFNT have reported better breathing and increased comfort. The myAirvo 3 delivers warm, moist air, which can reduce lung strain. Early findings also suggest it may help clear mucus more effectively than regular treatments. Overall, the myAirvo 3 shows promise in improving the quality of life for those with severe COPD.12567
Are You a Good Fit for This Trial?
This trial is for COPD patients aged 40+, who've had a severe exacerbation requiring hospitalization in the past 6 weeks. They must be able to use myAirvo 3 at home, record daily symptoms, and commit to the study's duration. Smokers with a ≥10 pack-year history can join if they meet specific lung function criteria (GOLD stages II-IV). Exclusions include certain sleep apnea scores, recent investigational drug use, life expectancy under 12 months due to other conditions, oxygen needs over 15 L/min, or inability to tolerate nasal prongs.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive home High Flow Nasal Therapy (HFNT) via myAirvo 3 plus usual COPD medical care
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- myAirvo3
- Pulse oximeter
myAirvo3 is already approved in United States for the following indications:
- Chronic Obstructive Pulmonary Disease (COPD)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Temple University
Lead Sponsor
Fisher and Paykel Healthcare
Industry Sponsor
Dr. Justin Vaughan
Fisher and Paykel Healthcare
Chief Medical Officer since 2024
MD from the University of Auckland
Lewis Gradon
Fisher and Paykel Healthcare
Chief Executive Officer since 2016
Bachelor of Science in Physics from the University of Auckland, New Zealand
Fisher & Paykel Healthcare
Collaborator