60 Participants Needed

Attention Bias Modification for Anxiety in Childhood Cancer Survivors

NL
Overseen ByNancy Lau, PhD
Age: < 65
Sex: Any
Trial Phase: Academic
Sponsor: Fred Hutchinson Cancer Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a treatment called Attention Bias Modification (ABM) to reduce anxiety in adolescent and young adult cancer survivors. Anxiety commonly affects these survivors and can lead to depression and sleep issues. ABM involves short, self-guided smartphone tasks to alter reactions to stressors and includes activities to enhance positive emotions. Participants will use either the ABM app or a similar task for four weeks. The trial seeks cancer survivors aged 15-29 who have completed treatment and have smartphone access. As an unphased trial, it offers participants the chance to contribute to innovative research that could enhance mental health support for cancer survivors.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators or your doctor.

What prior data suggests that Attention Bias Modification is safe for adolescent and young adult cancer survivors?

Research has shown that Attention Bias Modification (ABM) safely helps manage anxiety. In past studies, participants, including children and teens, handled ABM well, with no major reports of harmful side effects. This treatment uses a smartphone app to change reactions to anxiety-inducing stimuli. Participants complete tasks that encourage focus on neutral or positive things instead of negative ones. This method has lowered anxiety symptoms without causing discomfort or adverse effects. Overall, ABM appears to be a safe choice for managing anxiety, even for teens and young adults who have survived cancer.12345

Why are researchers excited about this trial?

Researchers are excited about Attention Bias Modification (ABM) for anxiety in childhood cancer survivors because it offers a novel approach compared to traditional therapies like cognitive-behavioral therapy or medication. ABM specifically targets the way attention is directed, helping patients shift focus away from anxiety-triggering stimuli. Unlike conventional methods that often require longer duration to see results, ABM sessions are brief and supplemented by engaging daily text prompts, potentially leading to quicker and more sustainable improvements in managing anxiety. The use of technology in the form of text messaging also makes this method accessible and easy to integrate into daily life, offering a modern twist to anxiety management.

What evidence suggests that Attention Bias Modification is effective for anxiety in childhood cancer survivors?

Research has shown that Attention Bias Modification (ABM), which participants in this trial may receive, can help reduce anxiety symptoms. Studies have found that children who participated in ABM often experienced a significant reduction in anxiety, with many no longer having an anxiety disorder. ABM helps individuals change their automatic reactions to stress by shifting focus away from threats and towards more neutral or positive thoughts. Using smartphone apps, ABM includes activities like identifying things to be grateful for, which can increase positive feelings. This method aims to improve anxiety symptoms in adolescents and young adults who have survived cancer.12678

Who Is on the Research Team?

NL

Nancy Lau, PhD

Principal Investigator

Fred Hutch/University of Washington/Seattle Children's Cancer Consortium

Are You a Good Fit for This Trial?

This trial is for adolescent and young adult cancer survivors who have experienced anxiety after battling childhood cancer, head and neck cancers, or leukemia. Participants should be comfortable using internet-based applications and willing to engage in interviews and questionnaires.

Inclusion Criteria

I am between 15 and 29 years old.
I have been diagnosed with cancer.
I received cancer treatment aimed at curing me at a specified hospital.
See 4 more

Exclusion Criteria

Patients who cannot understand/read/write English will be excluded from the research because the ABM intervention is currently only available in English
I am unable to take part in specific activities or answer surveys due to physical or cognitive reasons.
I am currently receiving treatment aimed at curing my cancer.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants engage in ABM or inert attention task sessions over 10 minutes twice a week and respond daily to text messaging prompts for 4 weeks

4 weeks
8 sessions (virtual), daily text prompts

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks
1 follow-up survey (virtual)

Open-label extension (optional)

Participants are given access to all components of ABM and texts on study after completion of the follow-up survey

What Are the Treatments Tested in This Trial?

Interventions

  • Attention Bias Modification
Trial Overview The study tests if attention bias modification (ABM) via smartphone apps can reduce anxiety by redirecting focus from negative triggers to neutral or positive stimuli. It includes gratitude exercises and aims to improve the mental health of young cancer survivors.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: Arm I (ABM)Experimental Treatment4 Interventions
Group II: Arm II (inert attention task)Active Control3 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Fred Hutchinson Cancer Center

Lead Sponsor

Trials
583
Recruited
1,341,000+

National Cancer Institute (NCI)

Collaborator

Trials
14,080
Recruited
41,180,000+

Published Research Related to This Trial

In a study involving anxious youth, adding Attention Bias Modification Treatment (ABMT) to 8 weeks of cognitive-behavioral therapy (CBT) did not enhance clinician-rated outcomes, but it did lead to earlier reductions in self-reported anxiety compared to CBT alone.
The research also showed that neural responses related to attention bias were stable in healthy youth, indicating that understanding these stable patterns could inform future ABMT strategies.
Training-associated changes and stability of attention bias in youth: Implications for Attention Bias Modification Treatment for pediatric anxiety.Britton, JC., Bar-Haim, Y., Clementi, MA., et al.[2021]
Long-term survivors of childhood acute lymphoblastic leukemia (ALL) who received cranial radiation therapy (CRT) showed significant attention deficits, particularly in shifting focus between local and global stimuli, compared to peers without a history of ALL.
Participants treated with only chemotherapy performed similarly to the non-ALL group, indicating that CRT is primarily responsible for the observed attention issues in survivors.
Visual attention in long-term survivors of leukemia receiving cranial radiation therapy.Schatz, J., Kramer, JH., Ablin, AR., et al.[2007]
A randomized controlled trial involving 53 youths with concerning anxiety levels showed that both attention bias modification treatment (ABMT) and attention control training (ACT) significantly reduced anxiety severity and global impairment after treatment and at a 2-month follow-up.
ACT was found to be more effective than ABMT in reducing anxiety severity at follow-up, suggesting that attention control may play a crucial role in improving anxiety outcomes in youths, highlighting the need for further research on the mechanisms of attention training.
Attention Training as a Low-Intensity Treatment for Concerning Anxiety in Clinic-Referred Youth.Pettit, JW., Rey, Y., Marin, CE., et al.[2023]

Citations

Attention Bias Modification for the Improvement of Anxiety ...This clinical trial studies how well attention bias modification (ABM) improves anxiety in adolescent and young adult (AYA) cancer survivors.
Attention Bias Modification for Anxiety in Childhood Cancer ...Studies have found that children who underwent ABM experienced significant decreases in anxiety symptoms, and many no longer met the criteria for anxiety ...
Efficacy of attention bias modification combined with ...A study of people with anxiety disorders suggested that ABM improved the therapeutic efficacy rate of CBT, and a comparison of the Intervention group (ABM + CBT) ...
Testing the effectiveness of combined attention modification ...Findings suggested that cTBS combined with AMT treatment was not superior to sham cTBS and AMT on reducing self-reported anxiety symptoms.
Attention Bias Modification for the Improvement of Anxiety ...This clinical trial studies how well attention bias modification (ABM) improves anxiety in adolescent and young adult (AYA) cancer survivors.
Examining the feasibility of cognitive bias modification...1. Active CBM training. Based on the evidence for attention but not interpretation bias in cancer survivors, 18 we trained attention bias only (in contrast to ...
Projects, Pediatric Pain and Sleep Innovations LabAims: 1) Characterize attention bias in AYA cancer survivors and relationships to patient-reported mental health outcomes. 2) Evaluate the feasibility and ...
Attention Bias Modification Treatment for Pediatric Anxiety ...The results suggest that ABM, but neither control condition, reduces pediatric anxiety symptoms and clinician severity ratings.
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