Activities-Based Locomotor Training for Cerebral Palsy

(ENGAGE-CP Trial)

This trial explores whether an Activities-Based Locomotor Training (AB-LT) program can improve the lives of young children with Cerebral Palsy who cannot walk independently. The researchers aim to determine if this intensive program, which includes treadmill walking and play-based therapy, is more effective than the usual care these children receive. Children who cannot walk as their primary means of mobility and can hold their head up for a few seconds may be suitable candidates for the trial. Participants must be willing to travel to Dripping Springs, Texas, and commit to a 7-week study period, including 3 weeks of intensive therapy sessions. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research that could enhance therapeutic options for children with Cerebral Palsy.

Research has shown that Activities-Based Locomotor Training (AB-LT) is generally safe for children with cerebral palsy. In past studies, children participated in intensive sessions that included walking and standing in a harness on a treadmill, along with play-based physical therapy. Trained physical therapists supervised these activities.

The studies found no major negative effects from this training, suggesting that AB-LT is a safe option for children. Since this treatment is non-invasive and similar to structured physical therapy, it is less likely to cause harm. However, like any physical activity, children might experience some discomfort or tiredness after sessions.

Activities-based locomotor training (AB-LT) is unique because it combines treadmill walking with play-based physical therapy in an intensive, structured program. Unlike standard treatments for cerebral palsy, which might involve varied and less frequent physical, occupational, or speech therapies, AB-LT offers a concentrated approach specifically designed to enhance motor skills through repetitive activity. Researchers are excited about AB-LT because it could potentially lead to quicker improvements in mobility and strength by providing consistent, focused training that targets walking and standing abilities in a supportive harness environment.

Research shows that Activities-Based Locomotor Training (AB-LT), which participants in this trial may receive, can improve movement in children with cerebral palsy (CP). Studies have found that this intensive program enhances skills like walking and standing. The program includes fun, play-based physical therapy, helping children learn and adapt through enjoyable activities. Early results suggest that AB-LT can reduce disability and improve the quality of life for children with CP who cannot walk. By boosting neuroplasticity, the brain's ability to change and adapt, this approach offers a promising path for rehabilitation.¹²³⁴⁶