Short Walks to Break Up Sitting for Type 2 Diabetes

MO
sc
Overseen Bystudy coordinator
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Minnesota
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial examines how breaking up long periods of sitting impacts heart health in people with type 2 diabetes. Researchers are testing three sitting patterns: sitting for 4 hours straight (prolonged sedentary behavior), sitting with a 5-minute walk each hour (breaking up sedentary behavior), and sitting with one 20-minute walk (breaking up sedentary behavior with a single 20-minute bout of self-paced walking). They aim to determine how these activities affect blood sugar and blood pressure. The trial seeks participants over 60 with type 2 diabetes who spend much of their day sitting. As an unphased trial, this study provides a unique opportunity to contribute to understanding lifestyle changes that could enhance heart health in people with type 2 diabetes.

Do I need to stop my current medications for the trial?

The trial protocol does not specify whether you need to stop taking your current medications.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research shows that taking short walks during long periods of sitting can be safe and might improve health in people with type 2 diabetes. Studies have found that brief movement can lower insulin levels and help the body manage sugar better. This suggests that short walking breaks are generally well-tolerated and could aid in diabetes management.

Recent studies indicate that even brief 20-minute walks can improve blood sugar levels. These findings suggest that walking, even for a short time, is a safe and possibly effective way to manage blood sugar in people with diabetes.

Overall, evidence suggests that both short walking breaks and longer walks are safe. They might help manage diabetes by improving blood sugar control without causing negative effects.12345

Why are researchers excited about this trial?

Researchers are excited about this trial because it explores a new approach to managing Type 2 Diabetes by breaking up prolonged sitting with short walks. Unlike traditional treatments that often involve medication or dietary changes, this method emphasizes physical activity as a simple, cost-effective intervention. The trial aims to determine if interrupting sitting time can improve blood sugar levels and overall health in a way that is both practical and accessible for individuals with Type 2 Diabetes. This approach is particularly appealing because it encourages a lifestyle change that can be easily integrated into daily routines without the need for medication adjustments or significant lifestyle overhauls.

What evidence suggests that this trial's treatments could be effective for type 2 diabetes?

Research has shown that taking breaks from long periods of sitting can improve health in people with Type 2 diabetes. Several studies have found that sitting less and taking short walking breaks help control blood sugar and lower blood pressure, reducing the risk of heart disease. In this trial, participants will join different groups to test these strategies. One group will engage in a single 20-minute bout of self-paced walking, while another group will take frequent short walking breaks. These approaches are based on findings that both a 20-minute walk and frequent short walks effectively manage blood sugar levels in people with diabetes. These findings suggest that breaking up sitting time with walking could be a helpful way to improve health in people with Type 2 diabetes.23678

Who Is on the Research Team?

MO

Mary O Whipple, PhD, RN, PHN

Principal Investigator

University of Minnesota

Are You a Good Fit for This Trial?

This trial is for people over 60 with Type 2 diabetes who are mostly inactive, sitting for more than 6 hours a day. It's not for those on dialysis, with a history of DVT, unstable conditions, recent hormone therapy changes, meeting exercise guidelines, physical disabilities affecting movement, Type 1 diabetes or uncontrolled high blood pressure.

Inclusion Criteria

I have type 2 diabetes with an A1c of 6.5% or higher.
I can avoid food, caffeine, alcohol, exercise for 24 hours, and smoking for 12 hours before each visit.
I am a woman and have not had a period for at least 12 months.
See 3 more

Exclusion Criteria

You have trouble thinking and understanding things clearly, which could make it difficult for you to agree to participate in the study.
You are physically active for at least 150 minutes a week, measured using a questionnaire.
Your blood pressure is very high and not under control.
See 6 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo 3 different sedentary behavior conditions to assess vascular function

12 weeks
Multiple visits for each condition

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • prolonged SB
  • SB broken 1
  • SB broken 2
Trial Overview The study tests how breaking up sitting time affects heart health in older adults with Type 2 diabetes. Participants will try three different routines: just sitting for four hours; walking five minutes every hour; and one longer walk of twenty minutes during the four hours.
How Is the Trial Designed?
3Treatment groups
Experimental Treatment
Group I: CONExperimental Treatment1 Intervention
Group II: BreakExperimental Treatment1 Intervention
Group III: BOUTExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Minnesota

Lead Sponsor

Trials
1,459
Recruited
1,623,000+

Published Research Related to This Trial

Sitting for long periods has harmful effects on cardiovascular and metabolic health, even for those who meet physical activity guidelines, highlighting the need to address sedentary behavior as a serious health risk.
Emerging evidence suggests that the physiological effects of inactivity are distinct from those of regular exercise, indicating that reducing sitting time and increasing breaks from sitting should be considered in health recommendations.
Too Little Exercise and Too Much Sitting: Inactivity Physiology and the Need for New Recommendations on Sedentary Behavior.Hamilton, MT., Healy, GN., Dunstan, DW., et al.[2022]
Breaking up prolonged sedentary behavior with light to moderate activity can significantly lower blood pressure in individuals at elevated risk for type 2 diabetes, based on a systematic review of 20 articles.
However, the limited number of studies and their inadequate statistical power for assessing other vascular health outcomes, like flow-mediated dilation, means more research is needed to fully understand the benefits of interrupting sedentary behavior.
Acute effects of sedentary breaks on vascular health in adults at risk for type 2 diabetes: A systematic review.Whipple, MO., Masters, KS., Huebschmann, AG., et al.[2022]
A 24-week behavioral modification program using pedometers and telephone support significantly increased physical activity by an average of 2744 steps per day and reduced sedentary behavior by 23 minutes per day in type 2 diabetes patients.
These positive changes in physical activity and reduced sedentary time were still evident one year later, with an increase of 1872 steps per day and a decrease of 12 minutes in sedentary behavior, demonstrating the program's lasting impact.
The effects of a pedometer-based behavioral modification program with telephone support on physical activity and sedentary behavior in type 2 diabetes patients.De Greef, KP., Deforche, BI., Ruige, JB., et al.[2022]

Citations

Health effects of reduced occupational sedentary behaviour in ...T2DM may not only lead to fatigue and impaired quality of life, but also increases the risk of cardiovascular disease and premature death [2]. Regular physical ...
Effects of Interrupting Prolonged Sitting with Physical Activity ...Physical activity (PA) breaks in sitting time might attenuate metabolic markers relevant to the prevention of type 2 diabetes. The primary aim of this paper ...
Walking for subjects with type 2 diabetes: A systematic ...Moreover, some recent studies have shown that even short bouts of walking, used for breaking prolonged sitting, can ameliorate glucose profiles in diabetic ...
Impact of a primary care-based mobile health intervention ...Conclusions. An mHealth programme effectively reduced sedentary behaviour, improved HbA1c and blood pressure, serving as a cost-effective lifestyle intervention ...
Efficacy of a personalised activity plan for BREAKing UP ...An 8-week personalised activity plan to break up sitting time shows promise as a treatment for people with IC, improving walking ability and reducing time ...
Sedentary behavior as a mediator of type 2 diabetes - PMCMeta-analysis (10 studies) suggest there is a 112% greater relative risk associated with a large duration of sedentary behavior for type 2 diabetes.
A study evaluating breaking up daily sedentary behavior inWe and others have found that interrupting sitting with short, 2-3 minute bouts of moderate activity (walking) can improve glucose tolerance during a single ...
Interrupting prolonged sitting with frequent short bouts of light ...Aim: To examine the impact of interrupting prolonged sitting with frequent short bouts of light-intensity activity on glycaemic control in ...
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