Personalized Molecular Profiling for Breast Cancer

(IMAGE-II Trial)

This trial aims to determine if genetic information from a simple blood test can match insights from a tumor biopsy and assist in guiding breast cancer treatment. It focuses on individuals with metastatic breast cancer who have previously undergone chemotherapy. Participants should have had a tumor biopsy in the last three years, with tissue still available for study. This trial may suit those with any type of breast cancer who can provide informed consent. As an unphased trial, it offers a unique opportunity to contribute to groundbreaking research that could enhance future breast cancer treatments.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research has shown that personalized treatment plans in cancer care enhance treatment effectiveness and reduce side effects. This approach involves analyzing a patient's genes to develop a treatment plan tailored to their unique genetic profile. Studies have found that this method helps doctors identify specific changes in a tumor's genes, guiding treatment choices. By targeting these changes, doctors often achieve better results with fewer side effects. These findings suggest that personalized treatment plans are generally safe and well-tolerated, as they aim to minimize unwanted side effects by customizing treatment for each individual.¹²³⁴⁵

Researchers are excited about Personalized Molecular Profiling for breast cancer because it offers a tailored approach to treatment. Unlike standard treatments like surgery, chemotherapy, or radiation, which are often applied broadly, this method uses genetic profiling to understand the unique characteristics of an individual's cancer. By analyzing both archival tissue and blood samples, this approach aims to identify personalized treatment recommendations that target specific genetic mutations. This could lead to more effective and less toxic treatments, offering hope for better outcomes and improved quality of life for patients.

Studies have shown that personalized molecular profiling can tailor breast cancer treatments by examining genetic information. In this trial, all participants will undergo genetic profiling to guide treatment decisions. Research indicates that this approach makes care more effective and can reduce side effects. One study analyzed the DNA of 103 breast cancer patients and identified specific genes linked to cancer. This enables doctors to select the best treatments based on the unique genetic makeup of a person's cancer. Personalized approaches like these are transforming cancer care and improving patient outcomes.¹³⁶⁷⁸