Broccoli Microgreens for Breast Cancer and Obesity

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Overseen ByYuanyuan (Rose) Li, M.D., Ph.D.
Age: Any Age
Sex: Female
Trial Phase: Academic
Sponsor: University of Maryland, Baltimore
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether eating broccoli microgreens, young and nutrient-rich broccoli plants, can help obese breast cancer survivors maintain health and reduce the risk of cancer recurrence. Researchers aim to determine if these microgreens improve metabolism and reduce inflammation, both crucial for lowering cancer risk. Participants will consume a cup of these microgreens daily for two weeks to assess adherence to this diet and observe bodily responses. Women who have completed breast cancer treatment, are classified as obese, and have no allergies to broccoli may be suitable for this study. As an unphased trial, this study provides a unique opportunity to contribute to groundbreaking research that could benefit future breast cancer survivors.

Do I need to stop my current medications for this trial?

The trial information does not specify if you need to stop taking your current medications. However, you must avoid cruciferous vegetables during the study and cannot take broccoli extract supplements.

What prior data suggests that broccoli microgreens are safe for human consumption?

Research shows that broccoli microgreens (BMG) are generally well-tolerated. Although clear information on negative effects in humans is lacking, studies with mice have demonstrated benefits for gut health and metabolism. This suggests BMG might be safe and beneficial for humans as well. Since this study is not part of a typical clinical trial, safety information is limited. However, as BMG is a type of food and broccoli is commonly consumed without major safety issues, BMG is likely safe for daily use.12345

Why are researchers excited about this trial?

Unlike standard treatments for breast cancer and obesity, which often involve medications, surgery, or extensive lifestyle changes, the use of broccoli microgreens offers a natural, dietary approach. Researchers are excited about this treatment because broccoli microgreens are rich in sulforaphane, a compound known for its potential anti-cancer and anti-obesity properties. This unique mechanism of action, targeting health at a cellular level through natural compounds, could provide a simpler and more holistic alternative to traditional treatments. Plus, consuming a cup of these microgreens daily is an easy and non-invasive method, potentially making it more accessible and appealing for patients.

What evidence suggests that broccoli microgreens might be an effective treatment for breast cancer and obesity?

Research has shown that broccoli microgreens, rich in nutrients, might help lower cancer risk. Animal studies have found that these microgreens can improve gut health and metabolism, which are crucial for better health in individuals with obesity. Some research suggests that compounds in broccoli microgreens, such as sulforaphane, may help fight cancer. Other studies have found that consuming broccoli-based foods can lower cancer risk. While more human research is needed, these findings suggest that broccoli microgreens could benefit breast cancer survivors dealing with obesity. In this trial, participants will consume one serving of raw broccoli microgreens daily for a 2-week period to evaluate these potential benefits.56789

Who Is on the Research Team?

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Yuanyuan (Rose) Li, M.D., Ph.D.

Principal Investigator

University of Maryland

Are You a Good Fit for This Trial?

This trial is for obese breast cancer survivors who are interested in exploring how a diet including broccoli microgreens (BMG) might impact their health and potentially reduce the risk of cancer recurrence. Participants should be willing to consume BMG daily.

Inclusion Criteria

Willing to avoid cruciferous vegetables during the study
Able to sign an IRB-approved consent form
I am female.
See 3 more

Exclusion Criteria

I am currently taking broccoli extract supplements.
Allergy or intolerance to cruciferous vegetables
I don't have any health issues that would prevent me from following the study's diet plan.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants consume one serving size (one cup, ~57 gram) of raw BMG daily for a 2-week period

2 weeks
Baseline visit and 2-week post-intervention visit

Follow-up

Participants are monitored for changes in metabolic parameters and gut microbiome after treatment

2 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Broccoli Microgreen
Trial Overview The study investigates if eating one cup of broccoli microgreens every day for two weeks can help manage weight, improve metabolism, and reduce inflammation in obese breast cancer survivors. It will measure changes in body fat, glucose levels, lipids, and gut bacteria.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: BMGExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Maryland, Baltimore

Lead Sponsor

Trials
729
Recruited
540,000+

University of Maryland, College Park

Collaborator

Trials
163
Recruited
46,800+

Citations

Broccoli Microgreen Metabotyping in Obese Breast Cancer ...This clinical trial is focused on exploring the potential health benefits of broccoli microgreens for obese breast cancer survivors.
Impact of Sulforaphane on Breast Cancer Progression and ...Another study found that maternal dietary broccoli sprouts (BSps) inhibited and prevented mammary cancer formation and exhibited suppressive ...
Broccoli Microgreens for Breast Cancer and ObesityTrial Overview The study investigates if eating one cup of broccoli microgreens every day for two weeks can help manage weight, improve metabolism, and reduce ...
Effects of long-term consumption of broccoli sprouts on ...Most of these reported effects are linked to anti-cancer properties and epidemiological studies have evidenced a decrease in the risk of cancer with the intake ...
Temporal Efficacy of a Sulforaphane-Based Broccoli Sprout ...Our study indicates a prenatal/maternal BSp dietary treatment exhibited maximal preventive effects in inhibiting breast cancer development.
Metabotyping of Broccoli Microgreen in Obese Breast ...Broccoli microgreens (BMG) are young broccoli plants packed with nutrients, and research suggests they may help prevent cancer.
Broccoli Consumption and Risk of Cancer - PubMed CentralBackground: The scientific literature has reported an inverse association between broccoli consumption and the risk of suffering from several types of cancer; ...
Broccoli Microgreens Nutrition: Everything You Need To ...Another study[8] has shown that eating broccoli microgreens inhibits breast cancer stems cells. The polyphenols and glucosinolates in broccoli ...
Metabotyping of Broccoli Microgreen in Obese Breast ...Broccoli microgreens (BMG) are young broccoli plants packed with nutrients, and research suggests they may help prevent cancer. Previous studies in mice showed ...
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