Psychological Options for Chronic Back/Neck Pain

(POWeR Trial)

JK
Overseen ByJonathan K Ashar, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Colorado, Denver
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to determine the most effective treatment for veterans experiencing long-term neck or back pain. It compares three approaches: Pain Reprocessing Therapy (PRT), Cognitive Behavioral Therapy for Chronic Pain (CBT-CP), and the care they are already receiving. Participants will be randomly assigned to one of these groups and will complete questionnaires about their pain and overall health. Veterans who have experienced moderate or severe back or neck pain for at least half of the past six months may be suitable candidates for this study. As an unphased trial, this study provides veterans with an opportunity to explore innovative therapies that could enhance their quality of life.

Do I need to stop my current medications for this trial?

The trial information does not specify whether you need to stop taking your current medications. It seems like you can continue your usual care, which may include your current medications.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Previous studies on Pain Reprocessing Therapy (PRT) have shown promising safety results. Specifically, 98% of patients improved, with 66% becoming pain-free or nearly pain-free, and no major safety issues were reported. Cognitive Behavioral Therapy for Chronic Pain (CBT-CP) is also well-tolerated. Research has shown it to be effective and safe, reducing pain and improving function. Participants have completed therapy sessions without major problems. Both therapies are non-invasive and manage pain through mental techniques instead of medication, making them generally safe options for those considering participation in such trials.12345

Why are researchers excited about this trial's treatments?

Researchers are excited about the treatments in this trial because they offer new psychological approaches to managing chronic back and neck pain. Pain Reprocessing Therapy (PRT) is unique because it focuses on retraining the brain's response to pain through education, mindfulness, and positive reinforcement, potentially breaking the pain-fear cycle and offering relief without medication. Cognitive Behavioral Therapy for Chronic Pain (CBT-CP), while already a leading approach, is also being tested to further validate and refine its effectiveness through structured sessions that teach skills like relaxation and cognitive coping. These therapies stand out from traditional medication or physical therapy options by addressing pain from a mental and emotional perspective, potentially leading to long-term benefits and improved quality of life.

What evidence suggests that this trial's treatments could be effective for chronic back/neck pain?

Research has shown that Pain Reprocessing Therapy (PRT), one of the treatments in this trial, can be very effective for chronic pain. In one study, 98% of participants who tried PRT experienced improvement, and 66% were either pain-free or almost pain-free by the end. Some even reported complete recovery from back pain after completing PRT sessions.

Cognitive Behavioral Therapy for Chronic Pain (CBT-CP), another treatment option in this trial, is also well-known for its effectiveness in managing chronic pain, particularly low back pain. It reduces pain in the short term and improves quality of life for many individuals. Studies indicate that both PRT and CBT-CP offer significant benefits for managing chronic pain, each using a different approach.12346

Who Is on the Research Team?

JK

Jonathan K. Ashar, PhD

Principal Investigator

University of Colorado, Denver

JW

Joseph W. Frank, MD, MPH

Principal Investigator

VA Eastern Colorado Health Care System

Are You a Good Fit for This Trial?

This trial is for veterans experiencing chronic neck or back pain. Participants will be randomly assigned to one of three treatments and must complete health questionnaires. Specific eligibility criteria are not provided, but typically include factors like age range, severity of pain, and willingness to adhere to the study protocol.

Inclusion Criteria

Veterans
I have had chronic back or neck pain for the last 6 months.
I am 18 years old or older.
See 1 more

Exclusion Criteria

I do not have any unstable or end-stage diseases, including active cancer.
Moderate or severe cognitive impairment
Current pain-related litigation outside the VA
See 13 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants are randomly assigned to receive either Pain Reprocessing Therapy (PRT), Cognitive Behavioral Therapy (CBT), or usual care. PRT and CBT involve nine weekly therapy sessions over video calls.

9 weeks
9 visits (virtual)

Follow-up

Participants are monitored for safety and effectiveness after treatment, with assessments at post-treatment and at 26, 39, and 52 weeks post-randomization.

52 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Cognitive Behavioral Therapy for Chronic Pain (CBT-CP)
  • Pain Reprocessing Therapy (PRT)
  • Usual Care
Trial Overview The POWeR Trial is testing Pain Reprocessing Therapy (PRT), Cognitive Behavioral Therapy for Chronic Pain (CBT-CP), and usual care to determine which is more effective in reducing pain and improving emotional functioning, quality of life, anxiety levels, and reducing pain medication use.
How Is the Trial Designed?
3Treatment groups
Experimental Treatment
Active Control
Group I: Pain reprocessing therapy (PRT)Experimental Treatment1 Intervention
Group II: Cognitive Behavioral Therapy for Chronic Pain (CBT-CP)Active Control1 Intervention
Group III: Usual CareActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Colorado, Denver

Lead Sponsor

Trials
1,842
Recruited
3,028,000+

VA Eastern Colorado Health Care System

Collaborator

Trials
55
Recruited
26,200+

United States Department of Defense

Collaborator

Trials
940
Recruited
339,000+

Citations

Cognitive‐behavioural treatment for subacute and chronic ...With regard to chronic neck pain, CBT was found to be statistically significantly more effective for short‐term pain reduction only when compared to no ...
Cognitive and Mind-Body Therapies for Chronic Low Back ...Cognitive Behavioral Therapy. The evidence for the effectiveness of CBT for the treatment of chronic neck pain is less robust than the evidence for low back ...
Cognitive Behavioral Therapy for Chronic PainProgram evaluation results indicate that the training in and implementation of these therapies have significantly enhanced therapist skills and Veteran outcomes ...
Efficacy and effectiveness of cognitive behaviour therapy ...Cognitive behaviour therapy (CBT) is the dominant force in contemporary psychological treatments for a very wide range of problems, including chronic pain.
Mindfulness vs Cognitive Behavioral Therapy for Chronic ...Results of the study suggest that both treatments have potential utility in treating adults with refractory CLBP and improving pain, function, and quality-of- ...
Comparing the clinical and cost-effectiveness of remote ...Cognitive behavioral therapy for chronic pain (CBT-CP) is an effective but underused treatment for high-impact chronic pain.
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