DuoTherm vs TENS for Lower Back Pain

No longer recruiting at 2 trial locations
AB
JS
Overseen ByJena Slaski
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: MMJ Labs LLC
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial compares two treatments for moderate to severe lower back pain: the DuoTherm device and Transcutaneous Electrical Nerve Stimulation (TENS). DuoTherm uses a belt to deliver vibrations, heat, cold, and pressure to relieve pain, while TENS uses electrical currents. Researchers aim to determine which treatment more effectively reduces pain and opioid use. Suitable participants have experienced significant lower back pain for an extended period and are willing to share details about their current pain medication. As an unphased trial, this study provides an opportunity to explore innovative pain relief methods and contribute to advancing treatment options.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but it does allow chronic opioid use for pain lasting 3 months or more. If you are on opioids for less than 3 months, you may not be eligible.

What prior data suggests that these treatments are safe for lower back pain?

Research has shown that DuoTherm, a new device for relieving back pain, is safe to use. Studies have found it effective in reducing pain with few side effects. DuoTherm eases pain through vibrations and pressure, avoiding drugs and typically reducing risks.

Limited information exists on negative effects, but available data suggests it is well-tolerated. Users of DuoTherm have reported few problems, making it a promising option for those seeking to avoid medication. Prospective participants should consult a healthcare provider before joining a trial.12345

Why are researchers excited about this trial's treatments?

DuoTherm is unique because it combines multiple modes of therapy—harmonic mechanical vibration, heat, cold, and pressure—into one wearable device for lower back pain relief. Unlike standard treatments like TENS units that focus solely on electrical stimulation, DuoTherm offers eight harmonic vibration patterns and five intensity levels, allowing for a tailored pain management experience. Researchers are excited about this multimodal approach because it targets pain relief from various angles, potentially offering more comprehensive relief for patients.

What evidence suggests that this trial's treatments could be effective for lower back pain?

Research shows that DuoTherm, a treatment in this trial for low back pain, effectively reduces pain using eight different vibration patterns. Studies have found that this type of mechanical stimulation can help with both sudden and long-term low back pain. Some patients in these studies regained normal function within six months. DuoTherm relaxes muscles and reduces swelling. While researchers continue to study its effect on lowering opioid use, it has already been shown to reduce pain levels.12367

Who Is on the Research Team?

JS

Jena Slaski

Principal Investigator

Sport and Spine Clinical Research Foundation

Are You a Good Fit for This Trial?

This trial is for adults aged 18-90 with acute low back pain lasting less than 3 months, who haven't been prescribed opioids for this episode. Participants must be able to understand the study and report on their medication use. Those with a BMI over 30, recent opioid prescriptions, pacemakers, certain medical conditions like Raynaud's or diabetic neuropathy, or skin issues in the low back area cannot join.

Inclusion Criteria

I understand the risks and benefits of the study.
I rate my pain or symptom as more than 4 on a scale of 0 to 10.
My pain has lasted less than 3 months and I haven't taken opioids for it.
See 2 more

Exclusion Criteria

I cannot use DuoTherm or TENS devices.
You weigh too much for the device to fit properly.
You have a pacemaker that would prevent you from using the TENS device.
See 7 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants use either the DuoTherm M-Stim device or TENS unit daily for 30 minutes

1 month
Daily use with remote data collection

Follow-up

Participants are monitored for opioid use and device effectiveness

3 months

What Are the Treatments Tested in This Trial?

Interventions

  • DuoTherm
  • TENS
Trial Overview The study compares DuoTherm therapy against TENS (Transcutaneous Electrical Nerve Stimulation) to see which one better reduces opioid use and eases acute lower back pain. Patients will self-report their pain levels and any medications taken during the trial period.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: Multimodal Harmonic Mechanical Stimulation Neuromodulation Wearable Belt (M-Stim)Experimental Treatment1 Intervention
Group II: Transcutaneous Electrical Nerve Stimulation (TENS)Active Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

MMJ Labs LLC

Lead Sponsor

Trials
4
Recruited
630+

Sport and Spine Rehab Clinical Research Foundation

Collaborator

Trials
21
Recruited
1,000+

National Institute on Drug Abuse (NIDA)

Collaborator

Trials
2,658
Recruited
3,409,000+

Published Research Related to This Trial

Transcutaneous electrical nerve stimulation (TENS) significantly reduces pain in patients with chronic low back pain, with a standardized mean difference of 0.844 indicating substantial improvement based on a meta-analysis of 13 studies involving 267 patients.
TENS treatment for less than 5 weeks showed significant pain relief, while longer treatments did not yield the same level of effectiveness, suggesting optimal treatment duration for pain management.
A Meta-Analysis of Transcutaneous Electrical Nerve Stimulation for Chronic Low Back Pain.Jauregui, JJ., Cherian, JJ., Gwam, CU., et al.[2022]
Transcutaneous electrical nerve stimulation (TENS) was found to be similar in efficacy to control treatments for pain relief in chronic back pain, indicating it may not be a superior option for managing pain compared to sham or placebo treatments.
However, TENS showed a significant short-term improvement in functional disability for patients with follow-up of less than 6 weeks, suggesting it may be beneficial for improving daily function in the early stages of treatment.
Literature Review and Meta-Analysis of Transcutaneous Electrical Nerve Stimulation in Treating Chronic Back Pain.Wu, LC., Weng, PW., Chen, CH., et al.[2022]
Transcutaneous electrical nerve stimulation (TENS) significantly reduces pain intensity during or immediately after treatment compared to placebo, based on a systematic review of 381 randomized controlled trials involving over 24,500 participants.
TENS also shows lower pain intensity compared to standard pharmacological and non-pharmacological treatments, with moderate-certainty evidence indicating it is effective and generally safe, as adverse events were mild and similar to those of comparators.
Efficacy and safety of transcutaneous electrical nerve stimulation (TENS) for acute and chronic pain in adults: a systematic review and meta-analysis of 381 studies (the meta-TENS study).Johnson, MI., Paley, CA., Jones, G., et al.[2022]

Citations

Preventing opioid prescribing for low back pain using ...A multimodal mechanical stimulation (M-Stim) device for LBP has demonstrated safety and efficacy in pain reduction, but its impact on opioid use has not yet ...
Impact of DuoTherm on Opioid Use and Low Back PainDuoTherm is a novel multimodal low back pain relief device incorporating 8 harmonic vibration patterns of mechanical stimulation (M-Stim) including ...
Novel multimodal mechanical stimulation is superior to ...Outcomes included 3-month resolution of aLBP and 6-month cLBP restoration of normal function (Pain Interference < 55), and exploratory outcomes in more at-risk ...
DuoTherm vs TENS for Lower Back Pain · Info for ParticipantsDuoTherm helps by relaxing muscles and reducing inflammation, while the other device blocks pain signals from reaching the brain. The electrical stimulation ...
Multimodal mechanical stimulation reduces acute and ...Multimodal mechanical stimulation reduces acute and chronic low back pain: Pilot data from a HEAL phase 1 study. April 2023; Frontiers in Pain ...
Novel multimodal mechanical stimulation is superior to TENS ...To direct the impulses, the DuoTherm device incorporates metal shaping to concentrate pressure on the paraspinal muscles while applying varying amplitudes of M ...
Lower Back Pain (DBCOND0030634)Clinical Efficacy and Safety of Axiom Worldwide DRX9000 Axial Decompression System for Treatment of Low Back Pain, No drug interventions, treatment, 2 ...
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