100 Participants Needed

Eye Tracking for Autism Detection

(RCFET Trial)

RM
AR
Overseen ByAngela R Paxton, BS
Age: < 18
Sex: Any
Trial Phase: Academic
Sponsor: Indiana University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to explore how eye-tracking technology can help detect autism in young children. Participants will engage in a simple activity where researchers track their eye movements as they view pictures and movies. This non-invasive method gathers data that might improve autism detection. Families with children aged 12 to 48 months visiting certain clinics for developmental evaluations, and who have English- or Spanish-speaking caregivers, might be a good fit for this study. As an unphased trial, this study offers families the chance to contribute to groundbreaking research that could enhance early autism detection methods.

Will I have to stop taking my current medications?

The trial information does not specify whether participants need to stop taking their current medications.

What prior data suggests that this eye-tracking method is safe for children?

A previous study found eye-tracking technology to be safe and easy to use. This tool reveals where and how long individuals focus their gaze, highlighting differences in attention. Eye-tracking has been applied to both children with autism and those without. Research has shown that this technology does not cause harm or discomfort. It is non-invasive, requiring no medical procedures or physical contact. Consequently, participants typically find it easy to engage in activities involving eye-tracking.12345

Why are researchers excited about this trial?

Researchers are excited about this trial because it's exploring eye tracking as a tool for detecting autism, which could revolutionize early diagnosis. Unlike current methods, such as behavioral assessments and parental questionnaires, eye tracking provides an objective and non-invasive way to analyze how children visually engage with their environment. This technique could potentially identify autism earlier and more accurately, allowing for timely interventions that can significantly improve developmental outcomes.

What evidence suggests that this eye-tracking method is effective for autism detection?

Studies have shown that eye-tracking technology can effectively diagnose autism. One study found that eye-tracking data was nearly 100% accurate in distinguishing children with autism from those without. Another study linked specific eye movement patterns to autism diagnoses. Research also shows that eye-tracking provides clear and consistent measurements, aiding early autism detection. In this trial, children undergoing a standard developmental evaluation will participate in a one-time eye-tracking activity to further explore its potential as a valuable tool for identifying autism in children.12678

Who Is on the Research Team?

RR

Rebecca R McNally Keehn, PhD, HSPP

Principal Investigator

IU School of Medicine

Are You a Good Fit for This Trial?

This trial is for young children aged 12-48 months who are patients at Riley Hospital for Children in Indiana. They must have caregivers who speak English or Spanish and can give consent. It's not open to kids younger than 12 months, older than 48 months, or those with non-English/Spanish-speaking caregivers.

Inclusion Criteria

My child is between 1 and 4 years old and has an appointment at Riley Hospital.
Children must have a legal guardian that is able to provide consent

Exclusion Criteria

My child is not between 1 and 4 years old.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Developmental Evaluation

Children undergo a standard of care developmental evaluation including a clinical interview and observational measures

1 day
1 visit (in-person)

Eye-Tracking Activity

Participants engage in a one-time eye-tracking activity to view pictures and movies while eye movements are tracked

15 minutes
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after the eye-tracking activity

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Eye Tracking
Trial Overview The study is testing a non-invasive eye-tracking system called Eyelink Portable Duo to see if it can help identify the risk of autism in young children during routine health care visits.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Children Undergoing Developmental EvaluationExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Indiana University

Lead Sponsor

Trials
1,063
Recruited
1,182,000+

Published Research Related to This Trial

A multisite study involving 280 children with autism spectrum disorder (ASD) and 119 typically developing children demonstrated that eye tracking (ET) tasks effectively measure attention to human faces, with the Oculomotor Index of Gaze to Human Faces (OMI) showing strong associations with cognitive and communicative skills in ASD.
The OMI has been accepted into the FDA's Biomarker Qualification program, indicating its potential as a reliable biomarker for clinical trials in ASD, although further research is needed to assess its effectiveness in real-world settings.
The autism biomarkers consortium for clinical trials: evaluation of a battery of candidate eye-tracking biomarkers for use in autism clinical trials.Shic, F., Naples, AJ., Barney, EC., et al.[2023]
In a study involving 74 children (37 with autism spectrum disorder and 37 typically developing), eye tracking revealed that children with ASD had significantly shorter fixation times on key areas of interest while watching a 10-second video.
The analysis showed that fixation times on the mouth and body could accurately distinguish between ASD and typically developing children with an accuracy of 85.1%, indicating that this method could be a promising tool for early detection of autism.
Applying Eye Tracking to Identify Autism Spectrum Disorder in Children.Wan, G., Kong, X., Sun, B., et al.[2021]
Eye tracking can effectively identify early signs of autism spectrum disorder (ASD) in young children, such as reduced attention to faces and difficulties in disengaging attention, which can appear as early as the first year of life.
In toddlers with ASD, specific altered looking patterns, particularly towards facial features like the eyes and mouth, as well as reduced responsiveness to biological motion, have been observed, suggesting that eye tracking can provide valuable insights into the neurocognitive aspects of autism.
Eye tracking in early autism research.Falck-Ytter, T., Bölte, S., Gredebäck, G.[2021]

Citations

Diagnosing autism spectrum disorder based on eye tracking ...On average, the LSTM model achieved excellent performance, with Non-ASD classifications showing 99.70% accuracy, 99.69% precision, 99.86% recall ...
Eye-Tracking Biomarkers and Autism Diagnosis in Primary ...In this prospective diagnostic study, a composite eye-tracking biomarker was associated with a best-estimate clinical diagnosis of autism.
The use of eye-tracking to find objective outcome ...Early intervention in autism lacks objective measures of treatment efficacy. · Literature shows that eye-tracking could be a clinically relevant ...
New eye tracking metrics system: the value in early ...Results: Our findings indicate significantly lower FAS and ASC and higher AVC (P<0.05) in children with ASD compared to their non-ASD counterparts within this ...
Accuracy of a 2-minute eye-tracking assessment to ...Eye-tracking could expedite autism identification/diagnosis through standardisation and objectivity. We tested whether Gazefinder autism ...
Applying Eye Tracking with Deep Learning Techniques for ...The dataset comprises raw eye-tracking data collected from 29 children diagnosed with autism spectrum disorder (ASD) and 30 typically developing (TD) children.
Eye-Tracking–Based Measurement of Social Visual ...To aid in early autism diagnosis, eye-tracking measurement of social visual engagement has shown potential as a performance-based biomarker.
Interest paradigm for early identification of autism spectrum ...This study aimed to identify objective biomarkers for ASD by integrating electroencephalography (EEG) and eye-tracking (ET) to analyze toddlers' visual ...
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