Insulin Treatment for Alzheimer's Disease

This trial explores whether insulin, typically used to control blood sugar, can enhance brain function in individuals with early Alzheimer's disease. Researchers aim to determine if administering insulin in pulses, rather than a steady stream, can boost brain energy and improve cognitive skills. The trial seeks participants with early Alzheimer's and insulin resistance, a condition where the body doesn't respond well to insulin. Participants will undergo tests of their cognitive and walking skills before and after the insulin treatment to assess any improvement. As an unphased trial, this study offers participants the chance to contribute to groundbreaking research that could lead to new Alzheimer's treatments.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research has shown that insulin can be safe for people with Alzheimer's. An early study demonstrated that insulin administered nasally improved memory without causing safety issues. Another study examined insulin's potential to protect the brain and help remove harmful proteins associated with Alzheimer's.

Unlike the standard Alzheimer's treatments, which often focus on managing symptoms through medications like cholinesterase inhibitors and memantine, physiologic insulin administration offers a novel approach by targeting the underlying metabolic dysfunctions associated with cognitive impairment. Researchers are excited about this treatment because insulin plays a crucial role in brain function and energy management, and its administration could directly enhance cognitive processes. Additionally, this approach could potentially modify disease progression rather than just alleviating symptoms, offering hope for more effective management of Alzheimer's disease.

Research has shown that insulin can improve thinking and memory in people with Alzheimer's Disease (AD). Some studies found that insulin slows the decline of memory and thinking skills in those with AD. Insulin might also aid memory problems and reduce certain harmful proteins in the brain. In conditions like Parkinson's Disease, short bursts of insulin have led to noticeable improvements. Although more research is needed, early results suggest that this insulin treatment could benefit brain health in AD. Participants in this trial will receive physiologic insulin administration to further explore its potential benefits for cognitive impairment in Alzheimer's Disease.⁶⁷⁸⁹¹⁰