Vagus Nerve Stimulation for Aging

(VNS Trial)

This trial explores whether stimulating the vagus nerve, a key nerve connecting the brain and gut, can improve memory in healthy older adults. Participants will receive either active nerve stimulation through Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) or a sham (inactive) treatment while performing memory tasks. The researchers aim to determine if this method can boost memory and how overall gut and brain health influence it. Ideal participants are older adults without memory issues or major health conditions that could affect brain function. As an unphased trial, this study offers participants the chance to contribute to groundbreaking research on memory enhancement.

The trial excludes people using medications known to alter cognition, so you may need to stop taking such medications to participate.

Research has shown that transcutaneous auricular vagus nerve stimulation (taVNS) is generally safe. Studies have found taVNS to be a promising, non-invasive method for addressing memory and cognitive issues. In one study, 70% of participants did not experience further memory decline after using a similar vagus nerve technique for six months.

Researchers are excited about Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) because it offers a novel, non-invasive way to potentially enhance memory function as we age. Unlike standard cognitive therapies or medications, taVNS stimulates the vagus nerve through the ear, possibly improving memory by enhancing brain activity during learning tasks. This approach is unique because it doesn't rely on drugs or lengthy interventions, and it could show benefits in a matter of minutes during specific memory tasks. This makes taVNS a promising candidate for those looking for alternative ways to maintain cognitive health without traditional medication.

Research has shown that transcutaneous auricular vagus nerve stimulation (taVNS) may improve memory and thinking skills. One study found that taVNS might enhance the ability to remember new information. Another study suggested it could aid immediate recall, the ability to remember things right away. Additionally, research indicates that taVNS can improve thinking skills by facilitating better cooperation among different parts of the brain. In this trial, participants will receive either active vagus nerve stimulation or sham stimulation to assess the effects on memory and cognitive function. These findings suggest that taVNS could be a promising non-invasive method to support memory and prevent memory loss in older adults.¹⁴⁶⁷⁸