TMS for Opioid Use Disorder and Alcoholism

(TMS4OUDAUD Trial)

This trial tests whether Transcranial Magnetic Stimulation (TMS), a non-invasive brain treatment, can aid recovery for individuals with opioid and alcohol addiction. TMS uses magnetic fields to stimulate specific brain areas, and the study examines different session lengths to determine the most effective. The goal is to assess if TMS can reduce cravings, alleviate withdrawal symptoms, and enhance overall mental and physical health. Suitable participants have been diagnosed with Opioid Use Disorder or Alcohol Use Disorder and are enrolled in an intensive outpatient program at Another Chance Rehab in Portland. As an unphased trial, this study provides a unique opportunity to explore innovative treatment options for addiction recovery.

If you are currently taking prescription benzodiazepines or anti-convulsive medications, you will need to stop taking them to participate in this trial.

Past studies have found that Transcranial Magnetic Stimulation (TMS) is generally well-tolerated by people with substance use disorders. Both high and low doses of TMS mainly caused mild side effects, such as headaches and scalp discomfort. These effects resemble those seen in TMS treatments for depression.

Researchers are excited about using Transcranial Magnetic Stimulation (TMS) for treating opioid use disorder and alcoholism because it offers a non-invasive approach that directly targets brain activity. Unlike traditional treatments that often rely on medication or behavioral therapy, TMS uses magnetic fields to stimulate nerve cells, which can alter brain circuits involved in addiction. The study includes a 3-minute and a 9-minute TMS session, both of which are quick and could potentially integrate seamlessly with daily therapy activities, offering flexibility and potentially faster results. This novel mechanism of action and delivery method could provide a promising alternative for individuals seeking treatment for substance use disorders.

Research has shown that Transcranial Magnetic Stimulation (TMS) could help treat substance use problems, such as opioid and alcohol addiction. Studies have found that TMS can reduce cravings and aid recovery. Specifically, repetitive TMS targeting the brain's prefrontal cortex has proven effective for opioid addiction. TMS is considered safe, with generally manageable side effects. In this trial, participants will receive either a 3-minute or 9-minute session of TMS, representing different doses. Both high and low doses of TMS have been studied, and evidence suggests they can enhance therapy engagement and improve mental health.¹⁶⁷⁸⁹