Deep Transcranial Magnetic Stimulation for Alcoholism
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether deep transcranial magnetic stimulation (dTMS) can help veterans with Alcohol Use Disorder (AUD) avoid relapse. The treatment uses magnetic fields to target specific brain areas. Participants will receive either the real treatment or a sham (fake) version for comparison. Veterans diagnosed with moderate to severe AUD and stable enough to attend regular sessions might be suitable candidates.
As an unphased trial, this study allows veterans to contribute to innovative research that could lead to new treatment options for AUD.
Will I have to stop taking my current medications?
If you are on a stable medication regimen for other symptoms, you can continue taking them during the study. However, you must stop taking any medications that increase seizure risk at least two weeks before treatment.
What prior data suggests that deep transcranial magnetic stimulation is safe for treating alcohol use disorder?
Research has shown that deep transcranial magnetic stimulation (dTMS) holds promise as a treatment for alcohol use disorder. Studies have found that dTMS can significantly reduce alcohol cravings. Regarding safety, dTMS is generally well-tolerated, with most individuals not experiencing severe side effects. Some may encounter mild headaches or discomfort at the application site, but these effects are typically temporary.
This treatment has been used for other conditions and has a history of safety in humans. Although this specific trial is not collecting new safety data, previous studies on dTMS suggest it is a safe option for most individuals considering it for alcohol use disorder.12345Why are researchers excited about this trial?
Researchers are excited about Deep Transcranial Magnetic Stimulation (dTMS) for alcoholism because it offers a non-invasive and innovative approach that differs from traditional options like medication and behavioral therapies. Unlike standard treatments, which often involve pharmaceuticals targeting neurotransmitter systems, dTMS directly stimulates specific brain regions associated with addiction control using magnetic fields. This method could potentially lead to faster and more effective results by directly influencing brain function, offering hope for those who haven't found success with current treatments.
What evidence suggests that deep transcranial magnetic stimulation is effective for alcohol use disorder?
Research has shown that deep transcranial magnetic stimulation (dTMS) can significantly reduce cravings for alcohol in people with Alcohol Use Disorder (AUD). One study reported a substantial decrease in craving scores, with a measure of -1.26, indicating a very significant effect. Another study found that dTMS reduced both cravings and alcohol consumption. This trial will compare active dTMS with sham dTMS to further investigate its effectiveness. These early results suggest that dTMS could be a promising method to help prevent alcohol relapse. However, more research is needed to confirm these findings on a larger scale.12356
Who Is on the Research Team?
Michelle R Madore, PhD
Principal Investigator
Stanford University
Claudia B Padula, PhD
Principal Investigator
Stanford University
Are You a Good Fit for This Trial?
This trial is for veterans with Alcohol Use Disorder (AUD) who are seeking treatment to reduce their risk of relapse. Specific eligibility criteria details were not provided, so it's important to contact the study organizers for more information on who can participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive 30 sessions of active or sham dTMS to the dACC/mPFC with the H7 coil, administered 3 times per day over 10 consecutive business days
Follow-up
Participants are monitored for changes in neural connectivity and alcohol consumption post-treatment
What Are the Treatments Tested in This Trial?
Interventions
- Deep Transcranial Magnetic Stimulation (dTMS)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Stanford University
Lead Sponsor