Balanced Salt Solution for Cataract Surgery

This trial tests two different salt solutions, Balanced Salt Solution (BSS) and BSS Plus, used during cataract surgery to determine which promotes better eye health afterward. The focus is on patients with cataracts and Fuch's Dystrophy, a condition affecting the cornea. Suitable participants have cataracts in both eyes and corneal issues like Fuch's Dystrophy but remain in stable health, with conditions such as controlled diabetes or high blood pressure. As a Phase 4 trial, the treatment has already received FDA approval and proven effective, allowing researchers to understand its benefits for more patients.

The trial information does not specify if you need to stop taking your current medications. However, it mentions that participants should have controlled type II diabetes and hypertension, which suggests you may continue medications for these conditions if they are well-managed.

Research has shown that BSS PLUS® Sterile Intraocular Irrigating Solution is safe for use in eye surgeries. Studies have found it to be well-tolerated during procedures like cataract surgery. For example, one study found that most patients completed the trial without any problems, and doctors rated it highly for safety. Additionally, FDA approval for use in other eye surgeries further supports its safety.

Researchers are excited about BSS Plus for cataract surgery because it enhances the standard Balanced Salt Solution (BSS) by adding nutrients that help maintain corneal health. Unlike the typical BSS, which is mainly used to keep the eye hydrated during surgery, BSS Plus includes additional components like bicarbonate, dextrose, and glutathione. These extras aim to better protect the eye's cells during the procedure, potentially leading to improved outcomes and faster recovery for patients.

Research has shown that BSS PLUS® Sterile Intraocular Irrigating Solution, a treatment in this trial, may improve cataract surgery outcomes. Studies have found that it maintains corneal cell health better than the standard BSS® solution, another treatment arm in this trial. For instance, one study found that BSS Plus more effectively preserved corneal cell size. Another study reported similar benefits for visual clarity after cataract surgery. Overall, BSS Plus appears to support better corneal recovery, which is crucial for clearer vision post-surgery.¹²⁴⁶⁷