Opioid Management Strategies for Postoperative Pain

This trial seeks better ways to manage pain after wisdom teeth removal while reducing opioid reliance. The focus is on a new pain relief method called the Twin block, a type of local anesthetic, to alleviate jaw pain after tooth extractions. Additionally, the trial uses an iPill Dispenser® to control and track opioid use, ensuring patients only use what they need. Individuals having wisdom teeth removed, with no history of jaw disorders or surgeries, and who own a smartphone are suitable candidates for this trial. As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, offering participants a chance to benefit from innovative pain management methods.

The trial requires that participants do not have a history of chronic use of certain medications like NSAIDs (non-steroidal anti-inflammatory drugs) or muscle relaxants. If you are using these regularly, you may need to stop before participating.

Research has shown that the Twin block, which uses lidocaine as a local numbing medicine, is generally safe. Studies have found that 2% lidocaine with epinephrine (a medicine that narrows blood vessels) works effectively and is usually well-tolerated. For instance, one study found this combination safe for dental procedures like wisdom tooth removal.

Most people do not experience serious side effects from lidocaine. Some might feel temporary numbness or a slight tingling sensation, which are normal and usually not a concern. In rare cases, an allergic reaction may occur, but this is uncommon.

Researchers are excited about the Twin block local anesthetic because it offers a targeted approach to managing postoperative pain after wisdom tooth extractions. Unlike standard treatments, which often rely on systemic opioids that affect the whole body, the Twin block method delivers local anesthesia directly to the surgical site. This approach uses a standard dental anesthetic, 2% lidocaine with epinephrine, to effectively numb the area, potentially reducing the need for opioids and minimizing their associated side effects. By focusing on local pain management, the Twin block may offer quicker recovery times and a safer, more comfortable experience for patients.

Research has shown that the Twin block, a type of local anesthetic, effectively reduces pain after dental surgeries like wisdom tooth extractions. In this trial, participants will receive either the Twin block local anesthetic or a control treatment. One study found that using lidocaine with epinephrine, components of the Twin block, significantly lowered pain levels just hours after surgery compared to other methods. Another study found that patients who received the Twin block needed less pain medication afterward, with 86.7% not requiring extra pain pills. These findings suggest that the Twin block provides quick and lasting pain relief, potentially reducing the need for opioids after surgery.⁵⁶⁷⁸⁹