Phentolamine Eye Drops for Night Vision Impairment

(LYNX-2 Trial)

This trial tests Phentolamine Ophthalmic Solution eye drops, which might aid those experiencing night vision issues after vision-improving surgeries like LASIK. It evaluates the safety and effectiveness of the drops for enhancing vision in low light. The trial includes two groups: one receives the active eye drops, and the other receives a placebo (inactive treatment). Individuals who have recently undergone vision correction surgery and face night vision problems, such as glare or halos, might be suitable for this study. As a Phase 3 trial, this study represents the final step before FDA approval, allowing participants to contribute to a potentially groundbreaking treatment.

Yes, you must stop using any topical prescription or over-the-counter ophthalmic medications, including artificial tear drops, at least 7 days before the trial and until it is completed. Additionally, you cannot change the dosage or start new systemic adrenergic or cholinergic drugs within 7 days before the trial or during the study.

The trial requires that you stop using any topical eye medications, including over-the-counter drops, at least 7 days before the screening and throughout the study. Additionally, you should not start or change any systemic adrenergic or cholinergic medications within 7 days before the screening or during the study.

Research has shown that Phentolamine Ophthalmic Solution is generally safe for use. In earlier studies, over 94% of side effects were mild, including eye discomfort and redness. Importantly, researchers did not link any serious side effects to the treatment. Tests for issues similar to night vision problems revealed no major safety concerns. This suggests that most people tolerate the treatment well.¹²³⁴⁵

Unlike most treatments for night vision impairment, which typically involve lifestyle modifications or surgical options, phentolamine eye drops are unique because they offer a non-invasive, pharmacological approach. Phentolamine works by improving blood flow in the eyes, which could enhance night vision more effectively and conveniently than current methods. Researchers are excited about this treatment because it could provide a daily-use solution that enhances night vision without the need for complex procedures or significant lifestyle changes.

Research has shown that Phentolamine Mesylate Eye Drops can enhance vision in dim light by reducing pupil size and sharpening vision. In this trial, participants will receive either the 0.75% phentolamine ophthalmic solution or a placebo comparator. One study found that 13% of patients using these drops improved their low-light vision test scores by at least 15 letters after just eight days. This finding suggests the drops can help with night vision problems. The treatment primarily aims to enhance contrast sensitivity and visual clarity. Overall, early results appear promising for those experiencing night vision issues after eye surgery.²⁴⁶⁷⁸