Computerized Cognitive Rehabilitation for ICU Survivorship

(RETURN-III Trial)

This trial explores a new method to assist individuals with cognitive problems, such as memory and thinking issues, after an ICU stay. The treatment uses computerized cognitive rehabilitation, which employs brain exercises to potentially improve these issues by leveraging the brain's ability to adapt and heal. Researchers aim to determine if this approach offers more benefits than regular computer games. The trial seeks adults who recently stayed in an ICU due to serious conditions like respiratory failure or shock and are now facing cognitive challenges. As a Phase 2 trial, the research focuses on measuring the treatment's effectiveness in an initial, smaller group.

The trial protocol does not specify whether you need to stop taking your current medications.

Research shows that computerized cognitive rehabilitation is generally safe. Studies involving individuals with brain injuries and strokes have demonstrated that this therapy is well-tolerated. For instance, a small study found that people recovering from serious illnesses with cognitive problems experienced significant improvements without major safety issues. Although detailed safety data from large groups is not yet available, the positive results so far are encouraging. This suggests that the treatment could be a safe option for those seeking to improve thinking skills after ICU stays.¹²³⁴⁵

Researchers are excited about computerized cognitive rehabilitation for ICU survivors because it offers a novel approach to tackling cognitive impairments that many patients experience after intensive care. Unlike traditional cognitive therapies that might involve face-to-face sessions with a therapist, this method uses digital platforms to deliver cognitive exercises, making it more accessible and potentially more engaging for patients. Additionally, this computerized approach can be easily customized to target specific cognitive deficits, providing a personalized therapy experience. By leveraging technology, this treatment has the potential to reach a larger number of patients, offering them an opportunity for cognitive recovery that fits into their daily lives more seamlessly.

Research has shown that computer-based exercises can greatly enhance thinking and memory in survivors of serious illnesses. In this trial, participants will join one of two groups: one group will receive Computerized Cognitive Rehabilitation, which studies have shown significantly improves memory and thinking problems. Another study found that a digital care program not only aided mental function but also enhanced physical and emotional health in seriously ill patients. These findings suggest that this therapy can aid recovery and improve overall care after ICU discharge. Starting cognitive exercises early has also been shown to maintain mental sharpness following an ICU stay. This treatment leverages the brain's ability to change and adapt, known as neuroplasticity, to potentially boost brain health.¹³⁴⁶⁷