Cognitive Behavioral Therapy for Insomnia in Brain Tumor Patients

(CBT-I in PBT Trial)

This trial examines the effectiveness of Cognitive Behavioral Therapy for Insomnia (CBT-I) in helping people with primary brain tumors who struggle with sleep. The main goal is to determine if this therapy can serve as a useful treatment option, enhancing overall wellbeing. Participants are divided into two groups: one receives regular care, while the other undergoes CBT-I through online sessions. Suitable candidates have a primary brain tumor, a diagnosis of insomnia according to standard guidelines, and the ability to attend weekly virtual meetings. As a Phase 2 trial, this research focuses on assessing the treatment's effectiveness in an initial, smaller group, offering participants a chance to contribute to significant findings.

The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators or your doctor.

Research has shown that Cognitive Behavioral Therapy for Insomnia (CBT-I) is generally safe for individuals with sleep difficulties. Studies have found that delivering CBT-I through telehealth is practical and well-received by patients, including those with primary brain tumors. A small initial trial demonstrated that this approach is safe and effective, with many participants continuing the treatment. Additionally, reviews of multiple studies confirm the safety of CBT-I, highlighting its long-lasting benefits without the side effects often associated with medications. This suggests that CBT-I is a well-tolerated option for improving sleep without significant negative effects.¹²³⁴⁵

Researchers are excited about Telehealth Cognitive Behavioral Therapy for Insomnia (CBT-I) in brain tumor patients because it offers a unique, remote approach to managing sleep issues. Unlike traditional in-person therapy, this telehealth method can be accessed from the comfort of a patient's home, making it more convenient and accessible, especially for those with mobility challenges. Additionally, CBT-I doesn’t rely on medication, reducing the risk of side effects and drug interactions, which can be particularly beneficial for patients who are already managing complex health conditions.

Research has shown that Cognitive Behavioral Therapy for Insomnia (CBT-I) effectively improves sleep for many people, including cancer survivors and those with brain injuries. One study found that online CBT-I with clinician support offers significant benefits for insomnia and related issues. Another review demonstrated that CBT-I greatly reduces insomnia symptoms in numerous studies involving thousands of people. This therapy combines methods that address the behaviors and thoughts causing insomnia. In this trial, participants will receive either Telehealth Cognitive Behavioral Therapy for Insomnia or Enhanced Treatment as Usual. Although researchers have not specifically tested CBT-I in patients with primary brain tumors, its success in similar groups suggests it might help those with brain tumors manage their insomnia as well.⁶⁷⁸⁹¹⁰