Virtual Reality Reward Training for Depression

This trial explores how virtual reality (VR) can help people with depression experience more positive emotions. It compares two VR experiences: Enhanced Virtual Reality-Reward Training (eVR-RT), which focuses on enjoying positive memories, and Virtual Reality-Memory Training (VR-MT), which enhances memory skills using neutral content. Participants will engage in one of these VR treatments for seven weeks. This trial suits individuals who struggle to enjoy positive experiences and feel that depression impacts their daily life. As a Phase 2 trial, the research measures the treatment's effectiveness in an initial, smaller group, allowing participants to contribute to developing new depression therapies.

Yes, you will need to stop taking any current psychotropic medications (drugs that affect your mood, thoughts, or behavior) to participate in this trial.

Research shows that virtual reality (VR) treatments, such as Enhanced Virtual Reality-Reward Training (eVR-RT) and Virtual Reality-Memory Training (VR-MT), are generally safe for treating depression. Studies have found that these VR therapies can improve depression symptoms without causing serious side effects. Some research indicates that these therapies help reduce anxiety and support thinking and memory in participants.

No major reports of negative reactions to the VR sessions have emerged from these studies. Participants did not experience harmful effects from the VR technology itself. Virtual reality provides a controlled and safe setting, allowing participants to engage in therapy exercises without real-world risks.

Researchers are excited about Enhanced Virtual Reality-Reward Training (eVR-RT) for depression because it offers a novel approach by combining virtual reality with positive memory training. Unlike standard treatments like antidepressants or cognitive behavioral therapy, eVR-RT immerses participants in positive virtual environments, helping them savor rewarding experiences and strengthen positive autobiographical memories. This technique could provide a more engaging and potentially faster-acting alternative, targeting the emotional and memory aspects of depression in a unique way.

This trial will compare two different virtual reality-based treatments for depression. Research has shown that Enhanced Virtual Reality-Reward Training (eVR-RT), one of the treatments in this trial, can help treat depression by making it easier for people to enjoy positive experiences. Studies have found that this VR method can lower symptoms of depression and stress by placing users in uplifting virtual settings, which may boost mood and mental health.