Behavioral Cough Suppression Therapy for Chronic Cough

This trial explores new methods to assist individuals with chronic cough unresponsive to standard treatments. It tests three approaches: Behavioral Cough Suppression Therapy, a hot pepper extract called capsaicin that may reduce cough sensitivity, and a combination of both. Participants will attend 12 sessions to evaluate the treatments' effects on cough sensitivity, cough control, brain response to cough triggers, and overall quality of life. The trial seeks adults with a long-term cough not explained by other health issues and unchanged despite normal lung tests in the past two years. As a Phase 2 trial, this research focuses on assessing the treatment's effectiveness in an initial, smaller group.

The trial information does not specify whether you need to stop taking your current medications. However, if you have used an ACE-inhibitor in the past 60 days, you cannot participate.

Research has shown that both behavioral cough suppression therapy (BCST) and capsaicin inhalation are generally safe for people with chronic cough. Studies have found that BCST can improve cough symptoms in up to 87% of patients. This therapy typically requires no more than four sessions and is considered effective and affordable.

For capsaicin inhalation, research suggests it is safe and well tolerated. Capsaicin, the ingredient that makes chili peppers spicy, has been used in various forms to reduce cough sensitivity. One study found that inhaling capsaicin is safe and tolerable, even for people with sensitive airways.

Researchers are excited about Behavioral Cough Suppression Therapy (BCST) because it offers a non-drug approach to managing chronic cough, differing from typical treatments like cough syrups and medications that primarily aim to suppress symptoms. This method focuses on training individuals to consciously control their cough reflex through specific behavioral techniques. Additionally, when combined with an inhaled vaporized drug, it potentially enhances the therapy's effectiveness by working to desensitize the cough reflex itself. This approach not only targets symptom relief but also addresses the underlying mechanism, potentially providing a more sustainable solution for chronic cough sufferers.

Studies have shown that behavioral cough suppression therapy (BCS) is effective for individuals with chronic cough. Many patients experience a significant reduction in cough frequency, with some studies indicating success up to 88% of the time. Research indicates that BCS helps patients better control their urge to cough and enhances their quality of life.