40 Participants Needed

Red Light Therapy for Artificial Light Exposure

NL
Overseen ByNicole L Lohr, MD, PhD
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: University of Alabama at Birmingham
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to determine if red light therapy (also known as photobiomodulation or low-level laser therapy) can improve blood flow in healthy adults. Participants will have their leg exposed to a specific type of red light and receive an ultrasound contrast to measure blood flow. This simple test evaluates whether the light can make a difference. Individuals who are generally healthy and do not have conditions like diabetes or heart issues may be suitable for this study. As an unphased trial, this study offers participants the chance to contribute to innovative research that could lead to new health insights.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that using 670 nm red light, like the one in this trial, is generally safe. Studies have found that red light therapy can improve blood flow and may even aid in brain injury recovery. This type of light is usually well-tolerated because it avoids the safety issues associated with lasers, making it easier and safer to use on large body areas.

Octafluoropropane is often used in medical imaging as a contrast agent. In this trial, it helps doctors see blood flow more clearly with ultrasound. Although detailed safety information is limited, it is commonly used in medical settings. Its use in this trial suggests a history of safety when used properly.

In summary, both treatments in this trial have evidence supporting their safety in humans. Red light therapy is known for being gentle, and octafluoropropane is a standard part of medical imaging.12345

Why are researchers excited about this trial?

Researchers are excited about the use of 670 nm red light therapy for artificial light exposure because it offers a unique, non-invasive approach by using a specific wavelength of light to improve blood flow. Unlike traditional treatments that might involve medication or lifestyle changes, this therapy uses a light-emitting diode positioned above the skin, avoiding direct contact and minimizing discomfort. Additionally, the treatment is paired with octafluoropropane infusion for precise blood flow measurement, allowing for real-time assessment of its effectiveness. This innovative method could provide a quicker, more targeted solution for issues caused by artificial light exposure.

What evidence suggests that red light therapy might be an effective treatment for stimulating blood flow changes?

Research has shown that 670 nm red light therapy, which participants in this trial will receive, can benefit several health areas. Studies have found it improves sleep and boosts endurance in athletes. It also protects eye cells, particularly those that detect light, preventing cell death. Additionally, a single session of 670 nm light can significantly enhance the ability to distinguish between colors. These findings suggest that 670 nm light therapy might also increase blood flow, given its positive effects on cell health and function.13678

Who Is on the Research Team?

NL

Nicole L Lohr, MD, PhD

Principal Investigator

Medical College of Wisconsin

Are You a Good Fit for This Trial?

This trial is for healthy adults aged 18-60, from any ethnic background. Participants must be able to understand and consent to the study in English. It's not suitable for those with heart or artery disease, high BMI, uncontrolled medical conditions, certain blood pressure levels, diabetes, kidney disease, neurological issues like stroke or cancer history.

Inclusion Criteria

I am either a man or a woman.
All ethnicities will be included in this study

Exclusion Criteria

I do not have any uncontrolled medical conditions.
Active pregnancy
I have a history of heart murmur or rhythm disorder.
See 15 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 visit

Treatment

Participants receive 670 nm red light exposure to the gastrocnemius muscle with concurrent blood flow measurements using contrast ultrasound

1 visit
1 visit (in-person)

Follow-up

Participants are monitored post-procedure for safety and effectiveness

10 minutes

What Are the Treatments Tested in This Trial?

Interventions

  • 670 nm light
  • octafluropropane
Trial Overview The study tests how red light at a wavelength of 670 nm affects blood flow when applied to the leg. Additionally, participants will receive an infusion of Definity (octafluoropropane) contrast agent during the procedure.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: 670 nm lightExperimental Treatment2 Interventions

670 nm light is already approved in European Union, United States, Canada for the following indications:

🇪🇺
Approved in European Union as Red Light Therapy for:
🇺🇸
Approved in United States as Photobiomodulation for:
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Approved in Canada as Low-Level Laser Therapy (LLLT) for:

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Alabama at Birmingham

Lead Sponsor

Trials
1,677
Recruited
2,458,000+

Medical College of Wisconsin

Lead Sponsor

Trials
645
Recruited
1,180,000+

Published Research Related to This Trial

Low-level light therapy (LLLT) has been shown to be effective for various skin conditions and wound healing, receiving clearance in the U.S. for cosmetic improvements and pain reduction, indicating its broad therapeutic potential.
Despite its widespread use, there is a lack of well-designed clinical trials that systematically evaluate the optimal parameters (like wavelength and energy dose) for LLLT, which can lead to confusion in its application for different types of wounds.
Wound Phototherapy.Bolton, LL.[2021]
Photodynamic therapy (PDT) effectively uses a photosensitizing drug activated by laser light for treating both cancer and non-cancer conditions, showcasing its versatility as a treatment option.
The report reviews clinical and preclinical studies involving Photofrin and other second-generation photosensitizers, highlighting advancements in the effectiveness and application of PDT.
Clinical and preclinical photodynamic therapy.Fisher, AM., Murphree, AL., Gomer, CJ.[2022]
Photodynamic therapy using red LED traffic lamps was effective in treating non-hypertrophic actinic keratoses in 15 patients, with all showing clinical improvement after just one session.
This method not only provided satisfactory results with minimal pain but also offers a cost-effective alternative to traditional, more complex photodynamic therapy light sources.
Low-irradiance red LED traffic lamps as light source in PDT for actinic keratoses.Enk, CD., Levi, A.[2013]

Citations

Red Light and the Sleep Quality and Endurance Performance ...The 14-day whole-body irradiation with red-light treatment improved the sleep, serum melatonin level, and endurance performance of the elite female basketball ...
Photobiomodulation: Lasers vs Light Emitting Diodes? - PMCIt can also be interpreted that both groups showed improved wound closure, though the data regarding the noncoherent red light is not shown in the study report.
Efficacy of 670 nm Light Therapy to Protect against ...Photobiomodulation at a wavelength of 670 nm has been shown to be effective in preventing photoreceptor cell death in the retina.
Weeklong improved colour contrasts sensitivity after single ...We show here that single 3 min 670 nm exposures, at much lower energies than previously used, are sufficient to significantly improve for 1 week cone mediated ...
Can infrared light really be doing what we claim it is doing? ...Near infrared (NIR) light has been shown to provide beneficial treatment of traumatic brain injury (TBI) and other neurological problems.
Photobiomodulation: shining a light on depression - PMCPhotobiomodulation (PBM), which involves the application of red or near-infrared light, modulates physiological processes by enhancing cerebral blood flow.
Photobiomodulation: A Systematic Review of the Oncologic ...This article presents a summary of the clinical and preclinical evidence for the oncologic safety of PBM for aesthetic skin rejuvenation.
Phototherapy for age-related brain diseasesResearch has shown that neuro-growth factor can be stimulated to induce neurite elongation through exposure to red light at 670 nm (Baratto et al., 2011).
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