Ethanol + Cannabinoid Effects on DUI

(THC-ETOH Trial)

This trial explores how alcohol and cannabinoids, such as THC from cannabis, affect driving and thinking skills. Participants will receive either active delta-9-THC, alcohol, both, or a placebo to assess the impact on simulated driving. This trial suits individuals who have previously tried both cannabis and alcohol. For those curious about how these substances might alter driving abilities, this presents an interesting opportunity. As a Phase 1 trial, the research focuses on understanding how these substances work in people, offering a unique chance to contribute to this knowledge.

The trial information does not specify whether you need to stop taking your current medications.

Research shows that both delta-9-THC (a compound in cannabis) and alcohol significantly affect the body. Studies indicate that delta-9-THC can slow reaction time, impair coordination, and alter perception, which are crucial for activities like driving. These effects can sometimes lead to reduced mental functioning and poorer driving skills.

For alcohol, research consistently shows it greatly impairs driving abilities. Drinking alcohol raises the risk of car accidents, especially as blood alcohol concentration (BAC) levels increase. Using both delta-9-THC and alcohol together increases these risks more than using either one alone, as their combined effects cause greater impairment.

Researchers are excited about exploring the effects of combining active delta-9-THC and ethanol on driving under the influence (DUI) because it targets interactions between cannabinoids and alcohol, which are commonly used substances. Unlike traditional DUI studies that often focus on a single substance, this trial examines how these two substances together might impair driving skills differently than when used alone. This approach could lead to a better understanding of how combined substance use impacts driving, potentially influencing future safety guidelines and interventions.

This trial will examine the effects of cannabis and alcohol on driving ability. Research has shown that both substances can impair driving skills. For cannabis, studies indicate that driving skills typically return to normal about 5 to 7 hours after use, although individuals often feel they must try harder to drive safely while under its influence. Alcohol is well-known for greatly increasing the risk of car accidents. Combining alcohol and cannabis often makes driving even more dangerous than using either substance alone. These findings underscore the risks of driving after using these substances. Participants in this trial will be assigned to different groups to assess the effects of active THC, active ethanol, or their combination on driving performance.⁴⁵⁶⁷⁸