Angiotensin II for Low Blood Pressure During Surgery

This trial aims to determine if Angiotensin II, a type of medication, can prevent low blood pressure in patients with high blood pressure undergoing surgery. Low blood pressure during surgery can harm vital organs, especially in those taking medications like ACE inhibitors or ARBs. The trial includes different groups based on the type of blood pressure medication participants use. Individuals with high blood pressure who have been on medications such as ACE inhibitors, ARBs, or similar drugs for over two months and are scheduled for surgery may be suitable for this trial. As a Phase 4 trial, this research seeks to understand how the already FDA-approved and effective treatment benefits more patients.

The trial does not specify if you need to stop taking your current medications. However, since it includes patients already on certain blood pressure medications, you might be able to continue them. Please confirm with the trial coordinators.

Research has shown that Angiotensin II is generally safe for use during surgery. Studies have found it to be well-tolerated by patients undergoing various surgeries, including those on the kidney, liver, heart, and lungs. Although some patients have experienced irregular heartbeats during surgery, medical teams carefully monitor these occurrences.

Researchers are excited about Angiotensin II for treating low blood pressure during surgery because it works differently from standard treatments like vasopressors. While traditional options often stimulate adrenergic receptors to raise blood pressure, Angiotensin II directly constricts blood vessels by mimicking a natural hormone in the body responsible for regulating blood pressure. This unique mechanism can offer a more targeted approach, potentially reducing the risk of side effects associated with other medications. Plus, its rapid onset can be particularly beneficial during surgery when quick blood pressure control is crucial.

Research has shown that Angiotensin II effectively treats low blood pressure during surgery. Studies have found that it can quickly raise blood pressure to safe levels. In this trial, participants will be divided into groups based on their current antihypertensive medications, such as ACE inhibitors, ARBs, or other classes, and will receive Angiotensin II. Previous findings suggest that Angiotensin II effectively manages low blood pressure, especially in patients taking medications like ACE inhibitors or ARBs. This treatment supports blood pressure without causing severe side effects. Overall, it has proven to be a reliable option for managing blood pressure issues during surgery.¹³⁴⁶⁷