Nutritional Optimization for Heart Failure

(ENOL Trial)

This trial aims to determine if the Ensure Surgery Immunonutrition shake can benefit individuals with severe heart failure who are about to receive a heart pump device, known as an LVAD. Researchers seek to discover whether consuming this shake before surgery can enhance gut health, reduce inflammation, and decrease complications such as infections or prolonged hospital stays. Participants will be grouped based on nutritional needs, with some consuming the shake once daily and others three times daily, to identify the most effective regimen. The trial is suitable for hospitalized patients preparing for LVAD surgery who are either well-nourished or at risk of malnutrition. As an unphased trial, it offers a unique opportunity to contribute to understanding how nutrition can affect surgical outcomes.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research shows that the Ensure Surgery Immunonutrition shake supports the immune system and aids recovery after surgery. This drink contains protein, arginine (an amino acid), and omega-3s, which help the body heal. Studies have found that these ingredients are usually well-tolerated and beneficial for post-surgery recovery.

Researchers are excited about the Ensure Surgery Immunonutrition shake because it offers a nutritional approach to support heart failure patients, particularly those undergoing LVAD implantation. Unlike standard heart failure treatments like medications or surgical interventions that primarily target heart function, this shake focuses on optimizing nutritional status. It's packed with essential nutrients and designed to boost immune function and recovery. This is especially important for malnourished patients, who receive a higher dosage, as good nutrition can significantly impact surgical outcomes and overall health.

Research has shown that the Ensure Surgery Immunonutrition shake can support the immune system and aid recovery after surgery. This shake contains 18 grams of high-quality protein, which helps repair tissues and heal wounds. It also includes omega-3 fatty acids, such as EPA and DHA, which can reduce swelling. Studies have found that reducing swelling and improving nutrition can lead to better surgical outcomes, including fewer infections and shorter hospital stays. In this trial, well-nourished participants will receive either 1 or 3 shakes per day, while those at risk for malnourishment or who are malnourished will receive 3 shakes per day. Although specific data for heart failure patients with LVADs is limited, the shake's ingredients are known to support overall recovery and health.¹²⁴⁶⁷