Nicotine Thresholds for Smoking Addiction

This trial explores how different nicotine doses affect smokers with varying dependence levels. Researchers aim to determine the dose at which smokers perceive nicotine, how rewarding they find it, and whether they prefer it over a non-nicotine option. Participants will experience various nicotine doses, including nicotine pouches, and compare them to a placebo (a substance with no active drug). Smokers who have been smoking at least once a week for a year or more and are otherwise healthy might be suitable for this study. As an Early Phase 1 trial, this research focuses on understanding how the treatment works in people, offering participants a chance to contribute to groundbreaking nicotine research.

The trial does not specify if you need to stop taking your current medications, but it excludes people who regularly use certain psychotropic medications (like those for mood disorders or anxiety). It's best to discuss your specific medications with the trial team.

Research has shown that nicotine, the main focus of this study, has been widely examined for its effects on the body. Many people use nicotine in products like patches or gum to help quit smoking, and these are usually well-tolerated. However, nicotine can cause side effects like dizziness, an upset stomach, or a faster heartbeat, especially at higher doses.

This study will test lower doses of nicotine. Lower doses are less likely to cause strong side effects. The study aims to find the smallest amount of nicotine that people can notice and that makes them feel good. By using these smaller doses, the researchers expect the safety risks to be lower.

Researchers are excited about this trial because it aims to pinpoint the precise nicotine levels that lead to smoking addiction. Unlike traditional treatments that focus on cessation, such as nicotine patches or gums that deliver a steady dose to curb cravings, this study explores how varying small doses of nicotine influence addiction. By understanding these thresholds, there’s potential to develop more effective strategies for prevention and treatment of smoking addiction, tailored to how individuals respond to different nicotine levels.

This trial will compare different doses of nicotine to saline to study nicotine's addictive properties and its potential to help reduce smoking. Research has shown that nicotine is highly addictive, which is why it's often found in smoking products. Studies have found that using nicotine in products like pouches or e-cigarettes can help people smoke less. Nicotine pouches, in particular, may help reduce smoking and might be less harmful than smoking cigarettes. These products provide nicotine without the dangerous chemicals in tobacco smoke. Although nicotine is addictive, using it in controlled amounts can help people manage their smoking habits.¹⁶⁷⁸⁹