iTBS for Alcoholism

This trial evaluates whether a new brain stimulation technique, intermittent theta-burst stimulation (iTBS), can assist individuals with alcohol use disorder (AUD) undergoing inpatient treatment. It compares iTBS to a placebo treatment to determine its effectiveness in reducing cravings and risky behaviors, as well as its impact on relapse rates after four months. Eligible participants should be right-handed, diagnosed with AUD, and planning to remain in a residential treatment program at Caron Treatment Centers for at least 28 days. The trial aims to enhance treatment effectiveness and potentially shorten its duration. As an unphased trial, this study provides a unique opportunity to contribute to innovative research that could improve treatment options for AUD.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.

Studies have shown that intermittent theta-burst stimulation (iTBS) is generally safe. Research indicates that iTBS shares a safety profile with repetitive transcranial magnetic stimulation (rTMS), a well-known treatment for various conditions. In trials with patients who have alcohol use disorder, iTBS was well-tolerated, with no major safety concerns reported. Another study found that iTBS was safe for veterans with PTSD, suggesting it does not cause significant side effects even in sensitive groups. Overall, evidence suggests that iTBS is safe, with most participants not experiencing serious adverse effects.¹²³⁴⁵

Researchers are excited about iTBS for alcoholism because it offers a novel approach by using brain stimulation. Unlike traditional treatments like counseling, medication, or support groups, iTBS involves brief bursts of magnetic pulses aimed at specific brain areas involved in addiction. This direct brain stimulation could potentially alter brain activity linked to cravings and dependency, providing a quicker, non-invasive method to complement existing therapies. Moreover, iTBS sessions are short, possibly leading to faster improvements compared to conventional treatments which often take weeks to show results.

Research has shown that intermittent theta-burst stimulation (iTBS) might benefit individuals with alcohol use disorder (AUD). In this trial, participants will receive either active iTBS or a sham iTBS treatment. One study applied active iTBS to a brain region involved in decision-making and impulse control, resulting in reduced alcohol cravings compared to a sham treatment. Another study found iTBS to be as effective and safe as traditional methods used for various conditions. Early results suggest that iTBS could reduce drinking by affecting brain areas linked to addiction. These findings offer hope for using iTBS to lower alcohol consumption and support recovery in individuals with AUD.¹²³⁴⁵