Intrathecal Morphine for Postoperative Pain
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial seeks the best way to manage pain after lung surgery using video-assisted or robotic techniques. Researchers are testing whether a small dose of morphine, given directly to the spine, can reduce the need for other pain medications and increase patient comfort. Participants will receive either the morphine treatment or a placebo (a harmless saltwater solution). The trial seeks participants undergoing elective lung surgery who will not require breathing support afterward. Individuals with severe liver or lung issues, chronic pain, or allergies to morphine are not suitable for this study. As a Phase 4 trial, this research involves an FDA-approved treatment and aims to understand its benefits for more patients.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. However, if you are using certain medications like oral steroids or have conditions like chronic pain, you may not be eligible to participate.
What is the safety track record for Morphine Sulfate?
Research has shown that intrathecal morphine, injected around the spinal cord, is generally safe and effective for post-surgical pain relief. It works well for specific types of pain that respond to opioid medications. Studies have found that it can reduce the need for other painkillers and lessen pain both at rest and during movement shortly after surgery.
The FDA has approved this treatment for managing both short-term and long-term pain when other options aren't enough. While usually safe, like any medication, it can have side effects. However, the chance of technical issues with this method remains low. Overall, intrathecal morphine offers a cost-effective way to manage pain after surgery with a good safety record.12345Why are researchers enthusiastic about this study treatment?
Intrathecal morphine is unique because it delivers pain relief directly into the spinal fluid, offering potentially faster and more effective pain control after surgery. This method stands out from standard pain management options, like oral or intravenous administration, which may take longer to act and can have more systemic side effects. Researchers are excited about this delivery method because it could lead to improved patient comfort and quicker recovery times, making postoperative pain management more efficient and targeted.
What is the effectiveness track record for intrathecal morphine in managing postoperative pain?
Research has shown that intrathecal morphine, which participants in this trial may receive, effectively manages post-surgical pain. Studies have found that it significantly reduces pain within the first 24 hours after an operation and decreases the need for other pain medications during recovery. This treatment has proven effective for various surgeries, including spinal procedures. Overall, intrathecal morphine provides strong pain relief, making it a reliable option for patients with acute post-surgical pain.23456
Are You a Good Fit for This Trial?
This trial is for adults aged 18-80 undergoing elective lung surgery (VATS) with expected immediate recovery from anesthesia. Candidates must understand English and not have severe health issues like advanced organ diseases, drug or alcohol abuse, chronic pain conditions, or be on life support treatments.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either intrathecal morphine or placebo during surgery
Follow-up
Participants are monitored for safety and effectiveness after treatment, including phone surveys at 1 and 3 months post-surgery
What Are the Treatments Tested in This Trial?
Interventions
- Morphine Sulfate
- Placebo
Morphine Sulfate is already approved in United States, European Union, Canada for the following indications:
- Pain management
- Acute pain
- Chronic pain
- Cancer pain
- Severe pain
- Acute pain
- Chronic pain
- Cancer pain
- Pain management
- Acute pain
- Chronic pain
- Cancer pain
Find a Clinic Near You
Who Is Running the Clinical Trial?
Northwestern University
Lead Sponsor
University of Chicago
Lead Sponsor