Lisinopril for Preventing Urinary Side Effects in Prostate Cancer Radiotherapy

This trial aims to determine the optimal dose of lisinopril for men with non-metastatic prostate cancer undergoing radiation treatment to manage urinary side effects. Although typically used to treat high blood pressure, researchers are investigating whether lisinopril can also alleviate urinary problems caused by radiation. Participants will receive either radiation alone or radiation with lisinopril to compare outcomes. Men with prostate cancer who are receiving radiation treatment and have not recently taken lisinopril or similar medications might be suitable for this study. As an Early Phase 1 trial, this research focuses on understanding lisinopril's effects in people, offering participants a chance to contribute to groundbreaking research.

The trial does not specify if you need to stop taking your current medications, but you cannot be taking lisinopril or similar drugs within two months before joining the study.

Research has shown that lisinopril, a medication commonly used to treat high blood pressure, is under study for its potential to alleviate urinary side effects in men undergoing radiation therapy for prostate cancer. The FDA has already approved lisinopril for other uses, confirming its well-known safety profile. Most people tolerate it well, though it can cause side effects like any medication. Common side effects may include dizziness or a cough, while serious side effects are rare. As this study is in the early stages, researchers are still determining the best dose and are carefully monitoring for any side effects. If lisinopril proves safe and effective, it could help reduce urinary problems caused by radiation therapy.¹²³⁴⁵

Most treatments for urinary side effects from prostate cancer radiotherapy focus on managing symptoms after they occur. But Lisinopril, a blood pressure medication, is being explored for its potential to prevent these side effects altogether. Researchers are excited because Lisinopril works by protecting blood vessels and tissues from radiation damage, which could mean fewer urinary issues for patients during and after their cancer treatment. This prevention-focused approach is quite different from current options that only address symptoms after they've developed.

Research has shown that lisinopril, which participants in this trial may receive, might help prevent urinary problems in men undergoing radiation treatment for prostate cancer. This medication, commonly used to lower high blood pressure, could improve blood flow to the urinary system. Improved blood flow might reduce urinary symptoms after radiation. Additionally, studies on similar drugs have demonstrated a decrease in some radiation-related side effects. While more research is needed, these early findings suggest that lisinopril could help manage urinary issues in this context.¹³⁵⁶⁷