CBD Oil for Postoperative Pain

(CBDS Trial)

This trial tests whether CBD oil (Cannabidiol Oil) can manage post-surgery pain as effectively as traditional opioid painkillers, such as Tramadol or Hydrocodone. Researchers will divide participants into groups, with one group receiving CBD oil and the other receiving standard opioid medications. The trial is ideal for individuals undergoing shoulder surgery who are open to trying CBD oil for pain relief instead of opioids. Participants must have scheduled shoulder arthroscopic surgery and be able to complete surveys and follow-up visits. As an Early Phase 1 trial, this study focuses on understanding how CBD oil works in people, offering participants a chance to explore this alternative pain management option.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research has shown that Cannabidiol (CBD) is generally safe for use. Studies indicate it can help manage pain without negative effects. However, CBD may cause side effects such as dry mouth, diarrhea, reduced appetite, and drowsiness.

Some studies also mention more serious side effects, like liver problems and fatigue, though these are less common. The FDA has approved CBD for other uses, suggesting that its benefits usually outweigh the risks.

Researchers are excited about using cannabidiol (CBD) oil for postoperative pain because it offers a natural alternative to traditional opioid painkillers like Tramadol and Hydrocodone/Acetaminophen. Unlike these opioids, which can be addictive and come with significant side effects, CBD oil is derived from the cannabis plant and is non-addictive. Additionally, CBD oil works by interacting with the body's endocannabinoid system, which may help reduce inflammation and pain without the high risk of dependency associated with opioids. This could make CBD oil a safer option for managing pain after surgery.

Research has shown that CBD oil might help reduce pain after surgery. For example, one study found that patients using CBD reported up to 25% less pain within two days after surgery compared to those who didn't use it. Another study suggested that CBD can be part of a pain management plan without affecting recovery. However, a review of several studies showed that CBD often didn't make a significant difference in pain relief. Overall, while some results are promising, the evidence on CBD's effectiveness for reducing pain after surgery remains mixed. This trial will compare the effects of two different dosages of Cannabidiol Oil (100 mg and 200 mg) with the standard of care for postoperative pain management.¹³⁶⁷⁸