Rose Odor for Epilepsy

This trial explores whether the scent of roses (2-phenylethanol rose scent) can help reduce the risk of Sudden Unexpected Death in Epilepsy (SUDEP) for people with epilepsy. Participants will stay in the hospital, where researchers will monitor their brain and breathing activities while exposing them to a rose scent for 24 hours. The trial seeks adults with epilepsy who are already scheduled for a routine 48-hour EEG monitoring session at Vanderbilt University Medical Center. As an Early Phase 1 trial, this research focuses on understanding how the rose scent works in people, offering participants a unique opportunity to contribute to groundbreaking research.

The trial does not specify if you need to stop your current medications. However, it mentions that there should be no changes in seizure medications during the 48-hour monitoring period.

Research has shown that 2-phenylethanol, a main component of rose scent, is generally safe. Studies have found that smelling rose scent might help individuals feel calm. Some possible risks include discomfort or a reaction to the scent, but these are usually minor. Participants might also experience discomfort from wearing a breathing belt, which is common when using such devices. Overall, existing evidence suggests that the treatment is well-tolerated.¹²³⁴⁵

Most treatments for epilepsy, like anti-seizure medications, work by stabilizing electrical activity in the brain. However, the rose scent treatment is unique because it uses 2-phenylethanol, a compound from rose oil, delivered through aromatherapy. This method introduces a non-invasive, potentially calming alternative that targets the brain through olfactory pathways. Researchers are excited about this because it could offer a new way to manage seizures without the side effects commonly associated with traditional medications.

Research has shown that the smell of roses, particularly 2-phenylethanol, might help calm people and reduce stress and depression. Early studies with mice suggested that this scent could lower the chance of death. This trial will compare two conditions: one group will be exposed to ambient rose scent via an aromatherapy diffuser, while another group will experience scentless room air. This offers hope for people with epilepsy, as it might reduce the risk of Sudden Unexpected Death in Epilepsy (SUDEP). The rose scent is generally safe, with few risks reported. While more research is needed, these early findings offer hope for its potential benefits in epilepsy care.¹²⁴⁶⁷