Ascorbic Acid for Skin Cancer

This trial tests a new treatment for squamous cell carcinoma, a type of skin cancer. Researchers aim to determine if a 30% ascorbic acid solution (a form of vitamin C) is as effective as the current 5% imiquimod cream. Participants will apply the ascorbic acid topically, directly on the skin, twice a day for eight weeks. Eligibility requires a confirmed case of squamous cell carcinoma and overall good health, with no history of other cancers or conditions like diabetes. As an Early Phase 1 trial, this research focuses on understanding how the treatment works in people, offering participants the opportunity to be among the first to receive this new treatment.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research shows that applying ascorbic acid to the skin can safely treat certain skin conditions. Studies have found that a 30% solution of ascorbic acid mixed with DMSO is usually well-tolerated, meaning most people experience no serious side effects. Vitamin C, the main component of ascorbic acid, often pairs with other skin products like sunscreen without causing issues. So far, no major reports of problems have emerged from using ascorbic acid on the skin, making it a promising option for those considering this treatment.¹²³⁴⁵

Unlike the standard treatments for skin cancer, which often include surgery, radiation, and chemotherapy, this new approach uses topical ascorbic acid, commonly known as vitamin C, in a unique delivery method. Researchers are excited about this treatment because it involves a direct application to the skin, allowing for targeted action with potentially fewer side effects. Additionally, ascorbic acid is known for its antioxidant properties, which might directly combat cancer cells in a novel way compared to traditional treatments. This innovative use of a well-known compound could offer a more accessible and less invasive option for patients.

Research has shown that vitamin C cream (topical ascorbic acid), which participants in this trial will receive, may help treat squamous cell carcinoma, a type of skin cancer. One study found it worked as well as, or even better than, imiquimod cream after eight weeks. Another study found it effective for treating both low-risk nodular and superficial skin lesions. Patients tolerated it well, experiencing few side effects. These findings suggest that vitamin C cream could be a good option for skin cancer treatment.¹²³⁶⁷